{"id":"W2066450795","doi":"10.1161/circulationaha.113.006720","title":"Proprotein Convertase Subtilisin Kexin Type 9 Promotes Intestinal Overproduction of Triglyceride-Rich Apolipoprotein B Lipoproteins Through Both Low-Density Lipoprotein Receptor–Dependent and –Independent Mechanisms","year":2014,"lang":"en","type":"article","venue":"Circulation","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":136,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cancer Care Ontario; Saint John Regional Hospital; Dalhousie University","funders":"National Heart, Lung, and Blood Institute","keywords":"Kexin; Proprotein convertase; PCSK9; Subtilisin; Medicine; Apolipoprotein B; Overproduction; Internal medicine; Triglyceride; Lipoprotein; Endocrinology; Apolipoprotein C2; LDL receptor; Very low-density lipoprotein; Biochemistry; Cholesterol; Biology; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002407966,0.0005923922,0.00114235,0.0002895051,0.0003078527,0.00008112095,0.0001914797,0.0004643131,0.0002169276],"category_scores_gemma":[0.001183826,0.0005501836,0.0002856233,0.0006080823,0.0002290672,0.0004775099,0.000149181,0.0006666391,0.00005803332],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003817599,"about_ca_system_score_gemma":0.0004104988,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006787625,"about_ca_topic_score_gemma":0.0002216064,"domain_scores_codex":[0.9948316,0.000483562,0.001122135,0.001265282,0.001627497,0.000669912],"domain_scores_gemma":[0.9967504,0.00005181312,0.0006767009,0.001408309,0.0007660094,0.000346818],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0029933,0.001324293,0.009192931,0.004174871,0.0005422306,0.00004943701,0.001553726,0.0001921674,0.8036036,0.009701357,0.0000756309,0.1665964],"study_design_scores_gemma":[0.006070046,0.002086526,0.1142716,0.0013115,0.0004670899,0.0007125043,0.0003001744,0.00340395,0.861025,0.008868556,0.0004927253,0.0009902671],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9535665,0.0005850708,0.03841541,0.0005992948,0.0005008373,0.005699828,0.00001540569,0.0002371313,0.0003805312],"genre_scores_gemma":[0.9888823,0.00007287628,0.009424707,0.0001285604,0.000792138,0.0002462582,0.0001625233,0.0001122503,0.000178386],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1656061,"threshold_uncertainty_score":0.9998263,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01465949671315806,"score_gpt":0.2430266661463432,"score_spread":0.2283671694331851,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}