{"id":"W2066450795","doi":"10.1161/circulationaha.113.006720","title":"Proprotein Convertase Subtilisin Kexin Type 9 Promotes Intestinal Overproduction of Triglyceride-Rich Apolipoprotein B Lipoproteins Through Both Low-Density Lipoprotein Receptor–Dependent and –Independent Mechanisms","year":2014,"lang":"en","type":"article","venue":"Circulation","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":136,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cancer Care Ontario; Saint John Regional Hospital; Dalhousie University","funders":"National Heart, Lung, and Blood Institute","keywords":"Kexin; Proprotein convertase; PCSK9; Subtilisin; Medicine; Apolipoprotein B; Overproduction; Internal medicine; Triglyceride; Lipoprotein; Endocrinology; Apolipoprotein C2; LDL receptor; Very low-density lipoprotein; Biochemistry; Cholesterol; Biology; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001622344,0.0003457198,0.0003131345,0.0002128756,0.0001000202,0.0002639226,0.0001281677,0.0002457213,0.001925029],"category_scores_gemma":[0.0001337842,0.0001642365,0.0003918552,0.0001542711,0.0002490351,0.0001538957,0.0002227742,0.0008422651,0.0004436999],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002452507,"about_ca_system_score_gemma":0.0001783383,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004108166,"about_ca_topic_score_gemma":0.0004358252,"domain_scores_codex":[0.999854,0.00002697808,0.00001667296,0.00002246953,0.00003846547,0.00004136502],"domain_scores_gemma":[0.9998129,0.00003625318,0.00005053331,0.00001880223,0.00002072926,0.0000607802],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006746207,0.0000701114,0.0002121797,0.00005472881,0.000005731104,0.0001154924,0.000008464984,0.00001750735,0.9980476,0.00002260567,0.00004521106,0.0007257585],"study_design_scores_gemma":[0.00009310338,0.001383604,0.01321697,0.0000119691,0.00002496555,0.0005430171,0.00004329057,0.0005820832,0.9823369,0.00003405377,0.001725278,0.000004754981],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957444,0.001360235,0.001174134,0.0001298926,0.00006065838,0.00002878523,0.0001966367,0.00008751282,0.001217717],"genre_scores_gemma":[0.9948825,0.001061464,0.001345689,0.00006185447,0.00002470751,0.00003210311,0.0003314042,0.00001656961,0.002243728],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001925029,"threshold_uncertainty_score":0.006439865,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01465949671315806,"score_gpt":0.2430266661463432,"score_spread":0.2283671694331851,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}