{"id":"W2066456246","doi":"10.1111/j.1528-1167.2008.01971.x","title":"Neurosteroids and epileptogenesis in the pilocarpine model: Evidence for a relationship between P450scc induction and length of the latent period","year":2009,"lang":"en","type":"article","venue":"Epilepsia","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Regione Emilia-Romagna; Canadian Institutes of Health Research; Fondazione Pierfranco e Luisa Mariani; Savoy Foundation","keywords":"Neuroactive steroid; Allopregnanolone; Pregnenolone; Cholesterol side-chain cleavage enzyme; Status epilepticus; Endocrinology; Internal medicine; Hippocampal formation; Epileptogenesis; GABAA receptor; Chemistry; Pharmacology; Biology; Neuroscience; Cytochrome P450; Epilepsy; Medicine; Receptor; Steroid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001066774,0.0004115316,0.0002807164,0.0004399289,0.0001169679,0.0002126737,0.0001981351,0.0003133158,0.001308287],"category_scores_gemma":[0.0002279329,0.0001313165,0.0002782585,0.0001742229,0.0004484973,0.000322363,0.0001873172,0.0007602601,0.0002331085],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003870667,"about_ca_system_score_gemma":0.0002333207,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006024885,"about_ca_topic_score_gemma":0.001086557,"domain_scores_codex":[0.999913,0.000009283349,0.00000809221,0.00001517887,0.00003045911,0.00002392145],"domain_scores_gemma":[0.9995871,0.00003883428,0.0002116525,0.000042784,0.0000236005,0.000096089],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001313509,0.0001465024,0.001613542,0.00004518941,0.00001659281,0.0002957852,0.00002616053,0.00004143927,0.9941136,0.00006842562,0.00005181204,0.002267412],"study_design_scores_gemma":[0.0001331755,0.003754265,0.08354568,0.0000215429,0.00009397556,0.001295122,0.00008737575,0.001476911,0.9082593,0.0002176194,0.001097406,0.00001747532],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960399,0.001235064,0.001516719,0.0001151107,0.00001896365,0.00003652586,0.0001854611,0.0001165333,0.0007356593],"genre_scores_gemma":[0.9973891,0.0005778856,0.0006610643,0.00003285629,0.00001053961,0.00004558686,0.0002382416,0.00001200849,0.001032581],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001308287,"threshold_uncertainty_score":0.00437665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2727594771735994,"score_gpt":0.4016506717331281,"score_spread":0.1288911945595287,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}