{"id":"W2066457589","doi":"10.1186/s12977-015-0150-z","title":"The CRISPR/Cas9 system inactivates latent HIV-1 proviral DNA","year":2015,"lang":"en","type":"article","venue":"Retrovirology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":214,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Program for Changjiang Scholars and Innovative Research Team in University; Peking Union Medical College; Canadian Institutes of Health Research; Chinese Academy of Medical Sciences","keywords":"CRISPR; Cas9; Genome editing; DNA; Virology; Biology; Gene; Jurkat cells; Computational biology; Genetics; T cell; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000297299,0.000557369,0.0004136322,0.0003340132,0.0002953418,0.0006069439,0.0005886377,0.0006703387,0.002188001],"category_scores_gemma":[0.0004047266,0.0002158835,0.0003486433,0.0001685293,0.0005039722,0.0002698216,0.0003636215,0.001164897,0.0007649398],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004911852,"about_ca_system_score_gemma":0.0005421984,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006663053,"about_ca_topic_score_gemma":0.0008337318,"domain_scores_codex":[0.9995049,0.00006523076,0.00006296497,0.0001305304,0.0001807963,0.00005562986],"domain_scores_gemma":[0.9997107,0.00006781393,0.00008853625,0.00004878589,0.00004602018,0.00003810843],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005747348,0.00003178346,0.0003803094,0.0001225828,0.0000157059,0.0001054964,0.00001420987,0.0002755811,0.9935606,0.0004129917,0.0001648814,0.004858449],"study_design_scores_gemma":[0.00001460055,0.0001871964,0.0008491032,0.00001350079,0.00002568062,0.0004590808,0.00001219849,0.002060681,0.9908439,0.0001622036,0.005360771,0.00001109745],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8524002,0.004352642,0.1256597,0.0006220258,0.0003075945,0.000413959,0.001622757,0.002248154,0.01237294],"genre_scores_gemma":[0.9333361,0.001600009,0.05728146,0.0001836291,0.00002729041,0.0001318564,0.001498159,0.00009938294,0.005842135],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002188001,"threshold_uncertainty_score":0.00731957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009639150517552578,"score_gpt":0.2666982627753903,"score_spread":0.2570591122578377,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}