{"id":"W2066461638","doi":"10.1371/journal.pone.0038032","title":"Ubiquitous [Na+]i/[K+]i-Sensitive Transcriptome in Mammalian Cells: Evidence for Ca2+i-Independent Excitation-Transcription Coupling","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Physiological and biochemical adaptations","field":"Environmental Science","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Canadian Institutes of Health Research; Kidney Foundation of Canada","keywords":"Extracellular; Transcriptome; Biology; HeLa; Molecular biology; Cell culture; Gene expression; Intracellular; Umbilical vein; Ouabain; HEK 293 cells; Transcription (linguistics); Transcription factor; Gene; Cell biology; Chemistry; Biochemistry; In vitro; Genetics; Sodium","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002391257,0.000139033,0.0001797849,0.00003008141,0.00009674865,0.00001743914,0.0001369739,0.00009319441,0.0002463516],"category_scores_gemma":[0.0000779486,0.0001226696,0.00007090013,0.0001944927,0.00009448262,0.0004195238,0.00002612544,0.0001371895,0.0002054796],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001683682,"about_ca_system_score_gemma":0.000006234991,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000173411,"about_ca_topic_score_gemma":0.00008171036,"domain_scores_codex":[0.9986998,0.00002990478,0.0002468175,0.0002850389,0.0003314897,0.0004069812],"domain_scores_gemma":[0.9994714,0.0001890136,0.0000535966,0.0001168689,0.00002077798,0.0001483673],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007801657,0.0009319286,0.002493361,0.00003943623,0.00001266001,8.371091e-7,0.0007462869,0.0002062799,0.9952226,0.00005775429,0.00003716528,0.0001737085],"study_design_scores_gemma":[0.0004163623,0.0001552574,0.1374713,0.0001466958,0.0000669474,6.595623e-7,0.0002917733,0.004237454,0.8559158,0.0009817141,0.00003674968,0.0002791859],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973164,0.0001151535,0.001388758,0.000337393,0.00006939138,0.000547732,0.00002614401,0.00004054263,0.0001584755],"genre_scores_gemma":[0.9956577,0.00003959093,0.003568812,0.0002412133,0.0001008052,0.0001420501,0.00002470046,0.00001121807,0.0002138504],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1393067,"threshold_uncertainty_score":0.500232,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1022911708198315,"score_gpt":0.2651543081221946,"score_spread":0.1628631373023631,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}