{"id":"W2066461638","doi":"10.1371/journal.pone.0038032","title":"Ubiquitous [Na+]i/[K+]i-Sensitive Transcriptome in Mammalian Cells: Evidence for Ca2+i-Independent Excitation-Transcription Coupling","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Physiological and biochemical adaptations","field":"Environmental Science","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Canadian Institutes of Health Research; Kidney Foundation of Canada","keywords":"Extracellular; Transcriptome; Biology; HeLa; Molecular biology; Cell culture; Gene expression; Intracellular; Umbilical vein; Ouabain; HEK 293 cells; Transcription (linguistics); Transcription factor; Gene; Cell biology; Chemistry; Biochemistry; In vitro; Genetics; Sodium","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000100678,0.0001970995,0.0003364945,0.0002423622,0.0001894961,0.000366327,0.0001399126,0.0002044543,0.0006780089],"category_scores_gemma":[0.0001967568,0.0001839757,0.0002958973,0.0002622043,0.0002373549,0.0001831546,0.0003035543,0.0002730867,0.0004357469],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002222538,"about_ca_system_score_gemma":0.0002309608,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009290458,"about_ca_topic_score_gemma":0.001155322,"domain_scores_codex":[0.999768,0.00001764572,0.00001748052,0.0001082707,0.00004930873,0.00003924358],"domain_scores_gemma":[0.9998276,0.00002436321,0.00004619732,0.00002786381,0.00004241367,0.00003138877],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003168758,0.000003313255,0.0008727139,0.00002062066,0.000004386877,0.00001880803,0.0000198039,0.00001413428,0.9984164,0.00002670842,0.00001165774,0.0005596854],"study_design_scores_gemma":[0.00001206917,0.0002752322,0.3142858,0.00001555748,0.00007418817,0.0008886133,0.0001653037,0.0009532335,0.6798393,0.0001823772,0.003289714,0.00001872664],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9773971,0.002614624,0.01486976,0.00008117445,0.00003022955,0.00005014136,0.002171988,0.0001588646,0.002626133],"genre_scores_gemma":[0.985141,0.001249866,0.00764494,0.0001294153,0.00002526796,0.00009141526,0.003741074,0.00004892312,0.001928115],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009290458,"threshold_uncertainty_score":0.002268136,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1022911708198315,"score_gpt":0.2651543081221946,"score_spread":0.1628631373023631,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}