{"id":"W2066471030","doi":"10.1074/jbc.m111.274381","title":"Lysosomal Acid Lipase Deficiency Impairs Regulation of ABCA1 Gene and Formation of High Density Lipoproteins in Cholesteryl Ester Storage Disease","year":2011,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Institutes of Health; Heart and Stroke Foundation of Canada","keywords":"ABCA1; Cholesteryl ester; ATP Binding Cassette Transporter 1; Multidrug resistance-associated protein 2; Reverse cholesterol transport; Liver X receptor; Cholesterol; Chemistry; Apolipoprotein B; Endocrinology; Internal medicine; High-density lipoprotein; Phospholipid; Lipoprotein; Biology; Biochemistry; ATP-binding cassette transporter; Transporter; Nuclear receptor; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000304911,0.000113875,0.0003899375,0.00005945375,0.0000157882,0.000004284431,0.00007573868,0.0001380846,0.00004262773],"category_scores_gemma":[0.0001685805,0.00007601939,0.0001097005,0.00009748765,0.0001224859,0.000141288,0.00004425626,0.0001918838,3.613555e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003054669,"about_ca_system_score_gemma":0.00004331205,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001285421,"about_ca_topic_score_gemma":9.878041e-7,"domain_scores_codex":[0.998923,0.00003490473,0.0006132768,0.0001176365,0.0001858899,0.000125292],"domain_scores_gemma":[0.9990042,0.00001881515,0.0005160423,0.0001505363,0.000135877,0.000174543],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001364289,0.0004142449,0.06149426,0.0002460607,0.000009906261,0.00003362416,0.0002491619,0.000004355227,0.933654,0.000006317291,0.000004380907,0.002519421],"study_design_scores_gemma":[0.001002509,0.0001779549,0.5678058,0.0001054365,0.00003970484,0.0001322626,0.00004599735,0.00002616874,0.4304774,0.0001348976,0.000006248515,0.00004562107],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989572,0.0005083684,0.0002523674,0.0000686108,0.0000445451,0.0001017422,0.000009947425,0.000004796983,0.00005240429],"genre_scores_gemma":[0.9989324,0.00009562219,0.0007614449,0.00003777224,0.0001441228,0.000001559673,0.000009735998,0.000004567888,0.00001278521],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5063115,"threshold_uncertainty_score":0.3099981,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02517281333245497,"score_gpt":0.231497891079962,"score_spread":0.2063250777475071,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}