{"id":"W2066471030","doi":"10.1074/jbc.m111.274381","title":"Lysosomal Acid Lipase Deficiency Impairs Regulation of ABCA1 Gene and Formation of High Density Lipoproteins in Cholesteryl Ester Storage Disease","year":2011,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Institutes of Health; Heart and Stroke Foundation of Canada","keywords":"ABCA1; Cholesteryl ester; ATP Binding Cassette Transporter 1; Multidrug resistance-associated protein 2; Reverse cholesterol transport; Liver X receptor; Cholesterol; Chemistry; Apolipoprotein B; Endocrinology; Internal medicine; High-density lipoprotein; Phospholipid; Lipoprotein; Biology; Biochemistry; ATP-binding cassette transporter; Transporter; Nuclear receptor; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002753565,0.0007276124,0.0007630563,0.0008416144,0.0003256348,0.0005125839,0.0002899913,0.0007928771,0.003029364],"category_scores_gemma":[0.0003221253,0.0003608956,0.000613101,0.000459416,0.0005756708,0.0002497718,0.0004925684,0.0006084101,0.001004409],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003821409,"about_ca_system_score_gemma":0.0002987039,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001030891,"about_ca_topic_score_gemma":0.000669449,"domain_scores_codex":[0.9995784,0.000075624,0.0001227024,0.00008924889,0.00008743447,0.00004651069],"domain_scores_gemma":[0.9996984,0.00007071056,0.00007720937,0.00002954803,0.00002634265,0.00009778728],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004320882,0.00009208736,0.0006857178,0.00004096387,0.0000185006,0.0007351965,0.00004068076,0.00005271968,0.9967242,0.000105924,0.00006283022,0.001009083],"study_design_scores_gemma":[0.0002082261,0.0008240269,0.03318066,0.00002957569,0.0001603259,0.01032105,0.0001775628,0.001930084,0.947141,0.0002037456,0.005792534,0.00003131487],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957587,0.001743201,0.0008862995,0.0001315943,0.00004764961,0.00002537515,0.0005734081,0.00008519237,0.0007486394],"genre_scores_gemma":[0.9954,0.001011633,0.0008686393,0.00006671762,0.00001282357,0.00003810664,0.00063918,0.00003691662,0.001926023],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003029364,"threshold_uncertainty_score":0.01013428,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02517281333245497,"score_gpt":0.231497891079962,"score_spread":0.2063250777475071,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}