{"id":"W2066488419","doi":"10.1002/pro.649","title":"Structural and enzymatic characterization of NanS (YjhS), a 9‐<i>O</i>‐Acetyl <i>N</i>‐acetylneuraminic acid esterase from <i>Escherichia coli O157:H7</i>","year":2011,"lang":"en","type":"article","venue":"Protein Science","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; National Research Council Canada; Biotechnology Research Institute; Institute for Biological Sciences; McGill University","funders":"Basic Energy Sciences; National Research Council Canada; National Center for Research Resources; Western Economic Diversification Canada; Biological and Environmental Research; Natural Sciences and Engineering Research Council of Canada; Brookhaven National Laboratory; Canadian Institutes of Health Research; National Institutes of Health; Canadian Light Source; U.S. Department of Energy","keywords":"Esterase; Sialic acid; Enzyme; Biochemistry; Chemistry; Neuraminidase; Hydrolase; Escherichia coli; Stereochemistry; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004044782,0.000178376,0.0001832993,0.0000885371,0.0001829296,0.00006872058,0.0004437921,0.00009774611,0.00009433798],"category_scores_gemma":[0.0002259495,0.0001589851,0.00004486177,0.0004207501,0.0006425721,0.00005005736,0.0002580942,0.0001220182,0.0000108663],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001285086,"about_ca_system_score_gemma":0.0001986301,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001127128,"about_ca_topic_score_gemma":0.00002562896,"domain_scores_codex":[0.9983066,0.00008880431,0.0003163842,0.0005282932,0.0004139691,0.0003459993],"domain_scores_gemma":[0.9989446,0.000007522043,0.0001867064,0.0004706508,0.000209165,0.0001813393],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008853504,0.00003183862,0.001753906,0.0000307446,0.000008033377,0.00000158576,0.0003699578,4.55159e-7,0.9955863,0.0001080089,0.000004276074,0.002016365],"study_design_scores_gemma":[0.0004724552,0.0003151931,0.02002761,0.00003438235,0.000006578023,0.000004032795,0.00005167186,0.0004745954,0.9779266,0.0001137854,0.0003904,0.0001827322],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997467,0.0001508872,0.001005889,0.00006631028,0.00007532971,0.0007473188,0.00005583783,0.00001636004,0.0004151106],"genre_scores_gemma":[0.9960685,0.00003561527,0.003358593,0.0001510722,0.00004709956,0.00008379302,0.00004725901,0.00001628123,0.0001918295],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01827371,"threshold_uncertainty_score":0.6483223,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02223139107058805,"score_gpt":0.2534102295215459,"score_spread":0.2311788384509579,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}