{"id":"W2066492659","doi":"10.1182/blood-2012-07-442558","title":"Comparison of primary human cytotoxic T-cell and natural killer cell responses reveal similar molecular requirements for lytic granule exocytosis but differences in cytokine production","year":2013,"lang":"en","type":"article","venue":"Blood","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":146,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"University of Chicago","keywords":"Exocytosis; Lytic cycle; Cytotoxic T cell; Cytokine; Cell biology; Biology; Natural killer cell; Granule (geology); Granzyme; Immunology; Chemistry; Perforin; Secretion; Biochemistry; In vitro; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001578835,0.0001879182,0.0002004992,0.00009842407,0.00006970712,0.0002817916,0.0001113209,0.0001589075,0.001671888],"category_scores_gemma":[0.000255574,0.00006349415,0.000286142,0.0001165543,0.00007548315,0.0001224155,0.00009766584,0.0001820905,0.0004094224],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003245519,"about_ca_system_score_gemma":0.0001305427,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005895894,"about_ca_topic_score_gemma":0.0004556934,"domain_scores_codex":[0.9999132,0.00001450749,0.000007586937,0.00002129527,0.00002238768,0.00002088314],"domain_scores_gemma":[0.9999099,0.0000383398,0.00001052771,0.00001331471,0.0000146132,0.0000133442],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006779471,0.0000642657,0.004108348,0.00007976187,0.00002577293,0.00009667638,0.00004790267,0.00548648,0.9818835,0.0005171318,0.0001112501,0.006900887],"study_design_scores_gemma":[0.00005774026,0.001124331,0.01964092,0.00001087163,0.000077733,0.0004365863,0.00006123274,0.03300933,0.9418406,0.000747761,0.002979468,0.00001350364],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901667,0.0007299362,0.007439618,0.00001858528,0.000006767069,0.0000184897,0.0003713763,0.00009541937,0.001153205],"genre_scores_gemma":[0.9963694,0.0003535108,0.001492638,0.00001417716,0.000002456371,0.00002286861,0.001107149,0.00001184007,0.0006259092],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001671888,"threshold_uncertainty_score":0.005593002,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0261306360820179,"score_gpt":0.26505309858846,"score_spread":0.2389224625064421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}