{"id":"W2066509694","doi":"10.1073/pnas.1400129111","title":"Protein phosphatase PP1/GLC7 interaction domain in yeast eIF2γ bypasses targeting subunit requirement for eIF2α dephosphorylation","year":2014,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"National Institutes of Health","keywords":"Biology; Protein phosphatase 1; Cell biology; eIF2; EIF4A1; Phosphatase; Phosphorylation; Protein subunit; Dephosphorylation; Eukaryotic translation; EIF4EBP1; Biochemistry; Translation (biology); Messenger RNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001063737,0.00007308021,0.0000791233,0.00007543453,0.0001034123,0.0000199684,0.0002474471,0.00006251314,0.000006570103],"category_scores_gemma":[0.0006868659,0.000056494,0.0000549257,0.0002194953,0.0001678049,0.00004517087,0.00005955335,0.00004557224,4.813614e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002262301,"about_ca_system_score_gemma":0.0000290573,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000695809,"about_ca_topic_score_gemma":5.117161e-7,"domain_scores_codex":[0.9990281,0.000009899118,0.000272482,0.0002025275,0.000376997,0.0001100213],"domain_scores_gemma":[0.9994265,0.00001845783,0.0003232982,0.000009518439,0.0001924225,0.00002984462],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001016191,0.00005224112,0.007393252,0.00004924479,0.000005884549,1.18493e-9,0.00003888003,0.0002824668,0.9748267,0.01598973,0.000680496,0.0005794958],"study_design_scores_gemma":[0.0004426326,0.00008327721,0.03504255,0.00006553632,0.000005214834,7.047131e-7,0.0001643697,0.00227014,0.946946,0.01156657,0.003325745,0.00008720867],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976422,0.000118289,0.0000734126,0.001067073,0.00001872974,0.0003399123,0.00001590313,0.000003816584,0.0007206784],"genre_scores_gemma":[0.9972285,0.000006677319,0.002405002,0.0001474165,0.00007889002,0.00004417223,0.00000542377,0.00000413327,0.00007977873],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02788065,"threshold_uncertainty_score":0.2303759,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02536560858408022,"score_gpt":0.3041351296263665,"score_spread":0.2787695210422863,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}