{"id":"W2066509694","doi":"10.1073/pnas.1400129111","title":"Protein phosphatase PP1/GLC7 interaction domain in yeast eIF2γ bypasses targeting subunit requirement for eIF2α dephosphorylation","year":2014,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"National Institutes of Health","keywords":"Biology; Protein phosphatase 1; Cell biology; eIF2; EIF4A1; Phosphatase; Phosphorylation; Protein subunit; Dephosphorylation; Eukaryotic translation; EIF4EBP1; Biochemistry; Translation (biology); Messenger RNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001128489,0.0004116069,0.0001636135,0.0001465994,0.0001885773,0.0003098548,0.0003742802,0.0002665475,0.001037765],"category_scores_gemma":[0.00008524735,0.0001769995,0.0002866121,0.0001868435,0.0003077363,0.0001401796,0.0002903576,0.0006991346,0.0007478879],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004877139,"about_ca_system_score_gemma":0.0003519813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001046297,"about_ca_topic_score_gemma":0.001814349,"domain_scores_codex":[0.999911,0.00001243625,0.000009821406,0.00002050974,0.00002580725,0.00002049152],"domain_scores_gemma":[0.9999349,0.00001082741,0.00001805371,0.00001235986,0.000005918129,0.00001790303],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005874653,0.00001785483,0.00006517604,0.00002590199,0.000004828564,0.00005211986,0.000007245043,0.00008960604,0.9989427,0.0001546825,0.00004053489,0.0005405776],"study_design_scores_gemma":[0.00002161514,0.00004465373,0.001463666,0.000005156912,0.0000108662,0.0001964948,0.00001675527,0.001009679,0.9941182,0.00006180053,0.003046244,0.000004906154],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925112,0.0007264431,0.004176742,0.0001564863,0.0000552347,0.00003562869,0.0004982401,0.0001416763,0.001698357],"genre_scores_gemma":[0.9898903,0.0006164939,0.004189748,0.0001247287,0.00001240099,0.00003675856,0.001573692,0.00007821398,0.003477623],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001046297,"threshold_uncertainty_score":0.003538609,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02536560858408022,"score_gpt":0.3041351296263665,"score_spread":0.2787695210422863,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}