{"id":"W2066529075","doi":"10.1128/jb.00200-11","title":"Bile Salts Induce Resistance to Polymyxin in Enterohemorrhagic Escherichia coliO157:H7","year":2011,"lang":"en","type":"article","venue":"Journal of Bacteriology","topic":"Escherichia coli research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Toronto Metropolitan University","funders":"Natural Sciences and Engineering Research Council of Canada; Universities Space Research Association; Public Health Agency; Public Health Agency of Canada; McMaster University","keywords":"Biology; Escherichia coli; Efflux; Microbiology; Polymyxin; Virulence; Bacterial outer membrane; Bacteria; Polymyxin B; Enterobacteriaceae; Signal transduction; Gene; Biochemistry; Antibiotics; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002176818,0.0004962689,0.0004843719,0.0003404136,0.0001538806,0.0004289514,0.0001486265,0.000415238,0.001117724],"category_scores_gemma":[0.0003774723,0.0002990889,0.0003418656,0.0001850707,0.0002400841,0.0001524303,0.0004471359,0.0005404011,0.0006462113],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002541952,"about_ca_system_score_gemma":0.0002092676,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007983217,"about_ca_topic_score_gemma":0.001121221,"domain_scores_codex":[0.9996426,0.00007722701,0.00003338364,0.00003831464,0.0001157039,0.00009270795],"domain_scores_gemma":[0.9996859,0.00005489535,0.0000572673,0.00003742328,0.00009621285,0.00006830957],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000656457,0.00002061933,0.0001824901,0.00001397364,0.000002905487,0.00002608743,0.00001179307,0.000008794779,0.9993227,0.000006201807,0.00001759014,0.0003212948],"study_design_scores_gemma":[0.00001437953,0.0006004506,0.01564413,0.000008957376,0.00001561999,0.0001280969,0.0001123955,0.0003020787,0.9824577,0.00003619564,0.0006702229,0.00000983175],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979429,0.0004691727,0.0004863823,0.0001171644,0.00002969445,0.00002484756,0.0002284749,0.00003926862,0.0006619945],"genre_scores_gemma":[0.9944544,0.0003884022,0.001304527,0.0001507408,0.00002060393,0.0000477209,0.0008325177,0.00005095953,0.002750073],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001117724,"threshold_uncertainty_score":0.003739178,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02356686706847567,"score_gpt":0.2747935369176172,"score_spread":0.2512266698491415,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}