{"id":"W2066531636","doi":"10.1016/j.bmcl.2015.03.029","title":"Enediynyl peptides and iso-coumarinyl methyl sulfones as inhibitors of proprotein convertases PCSK8/SKI-1/S1P and PCSK4/PC4: Design, synthesis and biological evaluations","year":2015,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Biochemical and Structural Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Genomics; Health Sciences Centre; Ottawa Hospital","funders":"","keywords":"Kexin; Proprotein Convertases; Chemistry; Furin; Subtilisin; Biochemistry; Proprotein convertase; Enzyme; Serine; In vitro; Cell growth; LDL receptor; Lipoprotein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000194487,0.000284058,0.0001792963,0.0001939622,0.00008758916,0.0002247933,0.0002673357,0.000174077,0.00109822],"category_scores_gemma":[0.0001153903,0.0001169005,0.0001239746,0.0001352844,0.0001408304,0.0002120438,0.0001214615,0.0003012834,0.0002424556],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002234091,"about_ca_system_score_gemma":0.0001744819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005034858,"about_ca_topic_score_gemma":0.0008424689,"domain_scores_codex":[0.9999359,0.00001270703,0.000006474292,0.000009293828,0.00001531198,0.00002044499],"domain_scores_gemma":[0.9999541,0.000007382172,0.00001048964,0.000004214261,0.000006982731,0.00001682816],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001989262,0.0003207484,0.0003937703,0.0001264416,0.00002541847,0.0002637466,0.0000518122,0.001947407,0.9682399,0.0007539627,0.0002174701,0.02567001],"study_design_scores_gemma":[0.0005979298,0.004307431,0.0023533,0.000008713959,0.0000601927,0.0003450468,0.00002933795,0.00173798,0.9825576,0.00009751025,0.007888863,0.00001608331],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903671,0.005015117,0.001535755,0.00007440041,0.00004674207,0.00007531727,0.000173907,0.00004146685,0.002670338],"genre_scores_gemma":[0.9908139,0.003460459,0.00143141,0.00003575307,0.0000115893,0.00003259828,0.0002197221,0.00000816974,0.003986442],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00109822,"threshold_uncertainty_score":0.003673911,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02750246406739295,"score_gpt":0.2514611524386064,"score_spread":0.2239586883712134,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}