{"id":"W2066531636","doi":"10.1016/j.bmcl.2015.03.029","title":"Enediynyl peptides and iso-coumarinyl methyl sulfones as inhibitors of proprotein convertases PCSK8/SKI-1/S1P and PCSK4/PC4: Design, synthesis and biological evaluations","year":2015,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Biochemical and Structural Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Genomics; Health Sciences Centre; Ottawa Hospital","funders":"","keywords":"Kexin; Proprotein Convertases; Chemistry; Furin; Subtilisin; Biochemistry; Proprotein convertase; Enzyme; Serine; In vitro; Cell growth; LDL receptor; Lipoprotein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003073492,0.0002664951,0.0003119984,0.00002780243,0.00007364084,0.00002571918,0.0001201962,0.0002594075,0.00003410133],"category_scores_gemma":[0.0009182147,0.0002049677,0.00003698625,0.00009537672,0.0006351999,0.00001319075,0.0001458328,0.0001236773,0.000001078027],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001998129,"about_ca_system_score_gemma":0.0000805765,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005419378,"about_ca_topic_score_gemma":9.451086e-7,"domain_scores_codex":[0.9987143,0.00008033851,0.000322388,0.0004362464,0.0002215799,0.0002251173],"domain_scores_gemma":[0.9992213,0.00007038223,0.0001593792,0.0001896387,0.0001190126,0.000240287],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001749602,0.0000213029,0.002884994,0.0001051631,0.0000584786,0.000004300091,0.00009784522,1.743232e-7,0.9951971,0.00000368342,0.0001916052,0.001260371],"study_design_scores_gemma":[0.00057741,0.0001764633,0.003466717,0.00004604364,0.000122919,0.0001469034,0.0002916857,0.00001533361,0.9946009,0.00007894176,0.0002286498,0.000248042],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955845,0.001569092,0.0002805178,0.002201648,0.00004461071,0.0002508111,0.00003122422,0.00001733501,0.00002019525],"genre_scores_gemma":[0.9983249,0.0002961214,0.0005296795,0.0004068597,0.0002485413,0.00003032173,0.0001116428,0.00001756387,0.0000343772],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002740327,"threshold_uncertainty_score":0.8358341,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02750246406739295,"score_gpt":0.2514611524386064,"score_spread":0.2239586883712134,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}