{"id":"W2066535896","doi":"10.1007/s11095-015-1675-5","title":"Unstirred Water Layers and the Kinetics of Organic Cation Transport","year":2015,"lang":"en","type":"article","venue":"Pharmaceutical Research","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"National Institute of Environmental Health Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute","keywords":"Kinetics; Transporter; Chemistry; Biophysics; Heterologous; Membrane transport; Organic cation transport proteins; Chinese hamster ovary cell; Enzyme kinetics; Biochemistry; Membrane; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001714824,0.00007551268,0.0001925887,0.00007808834,0.00004249196,0.000006999504,0.0001018777,0.00005812,0.0001677289],"category_scores_gemma":[0.00009660607,0.00003749372,0.00004077132,0.0002118144,0.0006395601,0.00002948121,0.00002123713,0.0003645944,0.00002896446],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003447393,"about_ca_system_score_gemma":0.00008326214,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002074925,"about_ca_topic_score_gemma":0.0000174433,"domain_scores_codex":[0.9984374,0.0001057636,0.0002056545,0.0001574919,0.0007692705,0.000324443],"domain_scores_gemma":[0.9990516,0.0001161072,0.00001131297,0.0001738462,0.000346497,0.0003006379],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009907682,0.0006263778,0.008483299,0.0006532164,0.0001828653,0.0001292241,0.006931947,0.000008011735,0.9480718,0.01844409,0.00068917,0.005872333],"study_design_scores_gemma":[0.009064104,0.0002443401,0.002632369,0.00006124775,0.0001729483,0.00002505762,0.0008005882,0.0006570241,0.9472679,0.004303062,0.03467096,0.0001003556],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9722249,0.0009406119,0.001690501,0.01781864,0.0001214142,0.000777853,0.000004479284,0.00002867533,0.006392956],"genre_scores_gemma":[0.9981627,0.000190727,0.0002080514,0.0001302065,0.00006475034,0.00001531545,0.00001589599,0.00001481247,0.001197538],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03398179,"threshold_uncertainty_score":0.2356486,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1919069369080724,"score_gpt":0.4416163066452896,"score_spread":0.2497093697372172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}