{"id":"W2066557153","doi":"10.1007/s10637-011-9673-x","title":"A phase II study of the halichondrin B analog eribulin mesylate in gemcitabine refractory advanced pancreatic cancer","year":2011,"lang":"en","type":"article","venue":"Investigational New Drugs","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"Juravinski Cancer Centre; Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Gemcitabine; Eribulin; Medicine; Internal medicine; Pancreatic cancer; Neutropenia; Gastroenterology; Phases of clinical research; Oncology; Progressive disease; Clinical endpoint; Refractory (planetary science); Adverse effect; Cancer; Metastatic breast cancer; Chemotherapy; Breast cancer; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001190513,0.001159358,0.002277913,0.0004683364,0.0004336774,0.0008930809,0.0008365808,0.001106812,0.003144664],"category_scores_gemma":[0.0006931683,0.0005426839,0.001002811,0.0004700531,0.0009917959,0.001035188,0.0003493374,0.00268823,0.0007296066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000790639,"about_ca_system_score_gemma":0.001097809,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001282236,"about_ca_topic_score_gemma":0.003241423,"domain_scores_codex":[0.9996219,0.0002094315,0.00001611504,0.00005206713,0.00002322806,0.00007728575],"domain_scores_gemma":[0.9994436,0.0001026469,0.00007519621,0.00006531311,0.00002547753,0.000287758],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7374949,0.08203226,0.0056532,0.0008620843,0.00148976,0.0005624188,0.0003835496,0.00499928,0.06086393,0.000445635,0.003273292,0.1019397],"study_design_scores_gemma":[0.4963288,0.4833533,0.008862546,0.00003409113,0.0005133993,0.0004013893,0.0001427749,0.001471385,0.005376342,0.0002627723,0.003212634,0.00004057605],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99475,0.001559368,0.0003659733,0.000345561,0.00008827083,0.0009529833,0.0004733956,0.00004322515,0.001421385],"genre_scores_gemma":[0.990971,0.00263449,0.0009673689,0.0005635799,0.000120969,0.001028304,0.001218415,0.00003100457,0.002464819],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003144664,"threshold_uncertainty_score":0.01051992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04866918016163396,"score_gpt":0.3410725055096305,"score_spread":0.2924033253479966,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}