{"id":"W2066569368","doi":"10.1007/s00210-012-0734-2","title":"Clozapine, atypical antipsychotics, and the benefits of fast-off D2 dopamine receptor antagonism","year":2012,"lang":"en","type":"review","venue":"Naunyn-Schmiedeberg s Archives of Pharmacology","topic":"Schizophrenia research and treatment","field":"Medicine","cited_by":80,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Clozapine; Antagonism; Dopamine receptor D2; Pharmacology; Dopamine; Medicine; Dopamine receptor; Schizophrenia (object-oriented programming); Neuroscience; Receptor; Psychology; Internal medicine; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003996434,0.0007521269,0.001560266,0.001350628,0.0001834841,0.0008386216,0.0006521427,0.000890278,0.002672889],"category_scores_gemma":[0.0005652708,0.0002089526,0.0004910149,0.001252764,0.0003292851,0.0005761958,0.0004082256,0.001244607,0.001059253],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005790027,"about_ca_system_score_gemma":0.0007272173,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002473565,"about_ca_topic_score_gemma":0.007583684,"domain_scores_codex":[0.9998784,0.00002076251,0.00001768657,0.00001947457,0.00004956899,0.0000141454],"domain_scores_gemma":[0.9998122,0.0001005732,0.00003578295,0.000005252808,0.00003139017,0.00001492949],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003937913,0.00006604214,0.000195654,0.0154135,0.0001935295,0.000336204,0.00003317249,0.0003003943,0.002021705,0.00227724,0.02284089,0.955928],"study_design_scores_gemma":[0.0002234063,0.0002583156,0.003259329,0.005590708,0.0005838419,0.002643126,0.00009192565,0.0001869893,0.0009180848,0.002684872,0.983521,0.00003843802],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001337587,0.9993006,0.00002297981,0.00008591216,0.00004432546,0.000001547695,0.00001285065,0.000002898888,0.000395009],"genre_scores_gemma":[0.00116122,0.9981809,0.00006818728,0.0001419427,0.00007294527,0.000002925635,0.00002250125,7.877117e-7,0.0003486955],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002672889,"threshold_uncertainty_score":0.00894165,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04241099216662504,"score_gpt":0.3617338988230523,"score_spread":0.3193229066564273,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}