{"id":"W2066583628","doi":"10.1097/qco.0b013e32835ba81c","title":"Evolution of HIV integrase resistance mutations","year":2012,"lang":"en","type":"review","venue":"Current Opinion in Infectious Diseases","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"U.S. Food and Drug Administration; Canadian Institutes of Health Research; Canadian Foundation for AIDS Research; amfAR, The Foundation for AIDS Research","keywords":"Integrase; Medicine; Human immunodeficiency virus (HIV); Virology; Integrase inhibitor; Mutation; Genetics; Computational biology; Antiretroviral therapy; Gene; Viral load; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001034683,0.0004034115,0.0012125,0.0007599493,0.00006472871,0.0000125533,0.00008744591,0.0001411689,0.0001723064],"category_scores_gemma":[0.0001782031,0.0003264346,0.000486814,0.0007761643,0.0001067298,0.0001079573,0.00004682966,0.0002901409,0.0002214062],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001000969,"about_ca_system_score_gemma":0.0008755052,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005420266,"about_ca_topic_score_gemma":0.000008214457,"domain_scores_codex":[0.9980839,0.0001548231,0.0008168164,0.0003562635,0.0002942259,0.0002939436],"domain_scores_gemma":[0.9987029,0.0001900201,0.0004147577,0.0003519035,0.0001238681,0.000216511],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005034305,0.004918316,0.07690454,0.1252303,0.000582683,0.000005883513,0.0002478479,0.000001880073,4.324193e-8,0.004941984,0.01996589,0.7671502],"study_design_scores_gemma":[0.0008231422,0.00002372751,0.001653087,0.04204581,0.001680417,0.00001387064,0.00002599516,0.000001923935,1.517661e-7,0.0002255984,0.953237,0.0002692815],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00001972145,0.9948884,0.0001383642,0.00002417146,0.002558663,0.001227198,0.0003350579,0.00009389798,0.0007145143],"genre_scores_gemma":[0.0008585986,0.9946331,0.00003766244,9.944807e-7,0.0004243168,0.0006291114,0.002639635,0.00004243233,0.0007340933],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9332711,"threshold_uncertainty_score":0.9999188,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05826734291732691,"score_gpt":0.3755644519799044,"score_spread":0.3172971090625775,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}