{"id":"W2066588420","doi":"10.1002/eji.201444689","title":"Patients with T<sup>+/low</sup> NK<sup>+</sup> IL‐2 receptor γ chain deficiency have differentially‐impaired cytokine signaling resulting in severe combined immunodeficiency","year":2014,"lang":"en","type":"article","venue":"European Journal of Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Deutsche Forschungsgemeinschaft; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research; Baxter International","keywords":"Biology; Common gamma chain; Severe combined immunodeficiency; Cytokine; Immunology; Degranulation; T cell; Signal transduction; Receptor; Phenotype; Cytokine receptor; Molecular biology; Immune system; Cell biology; Interleukin 10; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001122086,0.001184318,0.0003627062,0.0004850079,0.0003946377,0.0004214075,0.000191516,0.0004946995,0.0022051],"category_scores_gemma":[0.0004840956,0.0002190137,0.0002685072,0.0003152616,0.0004777527,0.000214418,0.0002588994,0.0004076316,0.0004988349],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001529078,"about_ca_system_score_gemma":0.0001302224,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004094968,"about_ca_topic_score_gemma":0.0003230433,"domain_scores_codex":[0.9998491,0.00002522557,0.00002820652,0.00004691206,0.00002261787,0.00002789102],"domain_scores_gemma":[0.9998029,0.00004594408,0.00005833255,0.00002016146,0.00001313744,0.00005963345],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.005093365,0.0004905969,0.3927996,0.0002817347,0.0002833076,0.0928641,0.001196938,0.001000445,0.4746387,0.0008298731,0.001031592,0.02948978],"study_design_scores_gemma":[0.0004341878,0.003025755,0.4984057,0.00005528877,0.000400632,0.4296783,0.0005091146,0.001469727,0.06048628,0.0004968758,0.004969709,0.00006843777],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985462,0.0001347287,0.0004282191,0.00003408981,0.000005723773,0.00001390063,0.0001240276,0.00002762832,0.0006855237],"genre_scores_gemma":[0.9988663,0.00008059188,0.0003164364,0.00003863928,0.00001674598,0.00001157889,0.0002819857,0.000008572267,0.0003790666],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0022051,"threshold_uncertainty_score":0.00737679,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007365862368864748,"score_gpt":0.1887646480837417,"score_spread":0.1813987857148769,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}