{"id":"W2066589698","doi":"10.1016/j.molcel.2009.11.021","title":"SH3 Domains from a Subset of BAR Proteins Define a Ubl-Binding Domain and Implicate Parkin in Synaptic Ubiquitination","year":2009,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":141,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University","funders":"Canadian Institutes of Health Research","keywords":"Parkin; Ubiquitin; Ubiquitin ligase; Biology; Endocytic cycle; Ubiquitin-Protein Ligases; Cell biology; SH3 domain; Phosphorylation; Genetics; Parkinson's disease; Receptor; Endocytosis; Gene; Proto-oncogene tyrosine-protein kinase Src; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001848636,0.0001667034,0.0001922003,0.00007984403,0.0000331242,0.00001523126,0.0001143399,0.0001722717,0.00001424979],"category_scores_gemma":[0.00001177862,0.0001784573,0.00007899009,0.0001140879,0.00004738398,0.000005037771,0.0000278168,0.00009492919,0.000003030774],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001639336,"about_ca_system_score_gemma":0.00003028133,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007407412,"about_ca_topic_score_gemma":0.00008121143,"domain_scores_codex":[0.9989174,0.00006117779,0.0002830006,0.0003742272,0.0001338363,0.0002303341],"domain_scores_gemma":[0.9995288,0.000005715606,0.0001002083,0.0002650387,0.00003179831,0.00006848263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008897,0.00009681926,0.002490089,0.00002342781,0.0000180805,0.0000390584,0.0001215583,0.00001905212,0.9962634,0.0002771522,0.000004398822,0.0005579281],"study_design_scores_gemma":[0.001435411,0.0003705512,0.01401722,0.00003879519,0.00003666085,0.000006535619,0.00006380524,0.0001188473,0.9804195,0.001653254,0.001583232,0.0002562013],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.971346,0.001094724,0.02632877,0.0001385082,0.00001609774,0.0003613788,0.00003571167,0.000009257354,0.0006696214],"genre_scores_gemma":[0.9956568,0.0001025331,0.002085974,0.00009662143,0.0000230298,0.00002004348,0.001975558,0.00001812708,0.00002124931],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02431093,"threshold_uncertainty_score":0.7277278,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004988639970874678,"score_gpt":0.2021080333342634,"score_spread":0.1971193933633888,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}