{"id":"W2066589757","doi":"10.1016/j.neuropharm.2013.06.005","title":"TC-8831, a nicotinic acetylcholine receptor agonist, reduces l-DOPA-induced dyskinesia in the MPTP macaque","year":2013,"lang":"en","type":"article","venue":"Neuropharmacology","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Toronto Western Hospital; Atuka (Canada); University Health Network","funders":"Michael J. Fox Foundation for Parkinson's Research","keywords":"Dyskinesia; MPTP; Parkinsonism; Medicine; Agonist; Nicotinic agonist; Levodopa; Amantadine; Anesthesia; Internal medicine; Pharmacology; Parkinson's disease; Endocrinology; Receptor; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000098718,0.00043689,0.0005080936,0.0004442885,0.0003059769,0.0002568523,0.0003988551,0.0006586221,0.001712818],"category_scores_gemma":[0.0001587844,0.0001860596,0.000208154,0.0001683422,0.0003269266,0.0002436218,0.0001126383,0.00087721,0.0004389117],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003532612,"about_ca_system_score_gemma":0.0003730767,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003857512,"about_ca_topic_score_gemma":0.007979924,"domain_scores_codex":[0.9998821,0.00001803353,0.00001063957,0.00001977784,0.00002776535,0.00004174811],"domain_scores_gemma":[0.9998544,0.00001489719,0.00003587737,0.00001474349,0.00001994353,0.00006009114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001047355,0.0002590833,0.0002922872,0.00005168217,0.00002017496,0.0001044846,0.00003116012,0.00003521519,0.9944869,0.0000415356,0.0001579789,0.003472118],"study_design_scores_gemma":[0.0002942391,0.007236302,0.01828297,0.00002445441,0.0001478853,0.0008974969,0.0001260097,0.001472658,0.9692843,0.00007575144,0.002138756,0.00001917493],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997916,0.0006506149,0.0002320877,0.0001218021,0.00002226142,0.00002435402,0.00016265,0.00006230034,0.0008079781],"genre_scores_gemma":[0.9929547,0.001123926,0.0009293674,0.0001135843,0.00002551232,0.00006156135,0.0004207131,0.00003702665,0.004333454],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003857512,"threshold_uncertainty_score":0.007670164,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01424910751544183,"score_gpt":0.2848400431096736,"score_spread":0.2705909355942318,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}