{"id":"W2066623013","doi":"10.1021/ol1004005","title":"Potent Glucosidase Inhibitors: De-<i>O</i>-sulfonated Ponkoranol and Its Stereoisomer","year":2010,"lang":"en","type":"article","venue":"Organic Letters","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; University of Toronto; University of Waterloo; Ontario Institute for Cancer Research","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Sulfonium; Counterion; Stereochemistry; Maltase; Catalysis; Enzyme; Biochemistry; Combinatorial chemistry; Organic chemistry; Ion; Salt (chemistry)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001052295,0.0005716504,0.0001885366,0.0001638991,0.00009257046,0.0001765577,0.000289881,0.0002207507,0.001193477],"category_scores_gemma":[0.00007719181,0.0001269626,0.0001608556,0.0001114919,0.000189119,0.0002724048,0.0001788674,0.0005130099,0.0004489999],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002001771,"about_ca_system_score_gemma":0.0001804878,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002242705,"about_ca_topic_score_gemma":0.0003323532,"domain_scores_codex":[0.9999254,0.00001285081,0.00000457039,0.00001676406,0.00001980381,0.00002069315],"domain_scores_gemma":[0.9999645,0.000004779087,0.0000125757,0.000002647763,0.000005346319,0.00001019047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001341685,0.00003591292,0.00006806592,0.0000879056,0.000008153213,0.00005107562,0.00001403468,0.0001706928,0.9916162,0.0006393123,0.0001648634,0.007009683],"study_design_scores_gemma":[0.00003277713,0.0003636355,0.0004614038,0.000003719323,0.000009457447,0.0001791299,0.000006026817,0.0002105674,0.9936605,0.00007251446,0.004994999,0.000005222355],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.940071,0.01106398,0.02709456,0.0003328165,0.0001322129,0.0002419013,0.0008566551,0.0004452829,0.01976158],"genre_scores_gemma":[0.9826154,0.004088474,0.006828079,0.0001315702,0.00003001143,0.00009669024,0.0006255971,0.00003949791,0.005544749],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001193477,"threshold_uncertainty_score":0.003992558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00541384152940419,"score_gpt":0.1878683653802896,"score_spread":0.1824545238508855,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}