{"id":"W2066650336","doi":"10.1359/jbmr.071213","title":"Enzyme Replacement Therapy for Murine Hypophosphatasia","year":2007,"lang":"en","type":"article","venue":"Journal of Bone and Mineral Research","topic":"Alkaline Phosphatase Research Studies","field":"Medicine","cited_by":259,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Shriners Hospitals for Children; National Heart, Lung, and Blood Institute; National Institutes of Health; National Institute of Dental and Craniofacial Research; Hospital for Special Surgery; Zorginstituut Nederland","keywords":"Hypophosphatasia; Enzyme replacement therapy; Rickets; Alkaline phosphatase; Internal medicine; Endocrinology; Osteomalacia; Vitamin D and neurology; Pyridoxal; Chemistry; Medicine; Enzyme; Biochemistry; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003906564,0.0009244472,0.0005809325,0.0006267334,0.0002387458,0.0004912555,0.0005878853,0.0008116931,0.003203476],"category_scores_gemma":[0.0001899467,0.0001720913,0.0004518843,0.000355213,0.0004522934,0.0003354934,0.0002714717,0.001598914,0.001461328],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006874534,"about_ca_system_score_gemma":0.0005059359,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005899706,"about_ca_topic_score_gemma":0.0005729156,"domain_scores_codex":[0.9996802,0.00005886098,0.00003383053,0.00006138479,0.0001076009,0.00005818127],"domain_scores_gemma":[0.9998246,0.00002512546,0.00005063028,0.00002806151,0.00002402156,0.00004754796],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001555817,0.0008580917,0.0004655715,0.0003959141,0.00006239444,0.000401654,0.00003986683,0.0003749058,0.9781514,0.0006520501,0.001281811,0.01576057],"study_design_scores_gemma":[0.000875395,0.008169724,0.002320765,0.0000678096,0.0001399113,0.002805329,0.00003841831,0.001477822,0.9381906,0.0001809275,0.04571271,0.00002065202],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9276389,0.03160082,0.01918655,0.001562757,0.001304329,0.0007922016,0.00420478,0.001800504,0.01190912],"genre_scores_gemma":[0.9598232,0.0113718,0.008940548,0.0004249425,0.0001456365,0.0007331807,0.005313664,0.00008849576,0.01315855],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003203476,"threshold_uncertainty_score":0.01071674,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1034850602293206,"score_gpt":0.4468702157781053,"score_spread":0.3433851555487847,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}