{"id":"W2066650336","doi":"10.1359/jbmr.071213","title":"Enzyme Replacement Therapy for Murine Hypophosphatasia","year":2007,"lang":"en","type":"article","venue":"Journal of Bone and Mineral Research","topic":"Alkaline Phosphatase Research Studies","field":"Medicine","cited_by":259,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Shriners Hospitals for Children; National Heart, Lung, and Blood Institute; National Institutes of Health; National Institute of Dental and Craniofacial Research; Hospital for Special Surgery; Zorginstituut Nederland","keywords":"Hypophosphatasia; Enzyme replacement therapy; Rickets; Alkaline phosphatase; Internal medicine; Endocrinology; Osteomalacia; Vitamin D and neurology; Pyridoxal; Chemistry; Medicine; Enzyme; Biochemistry; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008410365,0.0001292148,0.0004673146,0.0004882959,0.0001763388,0.00003370279,0.00008065583,0.00006124931,0.00005754076],"category_scores_gemma":[0.00152488,0.00008642288,0.0001447036,0.0003217892,0.0002104998,0.0001258029,0.0001026148,0.0005346269,0.000004441074],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001189732,"about_ca_system_score_gemma":0.0002663878,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000566238,"about_ca_topic_score_gemma":0.00001437302,"domain_scores_codex":[0.99732,0.00005596412,0.0006183048,0.0001864122,0.001179411,0.0006398936],"domain_scores_gemma":[0.9970616,0.0007197805,0.0001444727,0.0002063978,0.001445245,0.0004224787],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0502651,0.001612314,0.01129353,0.0005496938,0.001038013,0.002243507,0.0008502991,0.000001579348,0.1472396,0.001857077,0.5486676,0.2343818],"study_design_scores_gemma":[0.02320284,0.02028953,0.05133791,0.0004562276,0.00007888968,0.001641682,0.001694348,0.00009948205,0.1109803,0.002154524,0.7877858,0.0002785583],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8964043,0.09314953,0.0004652106,0.008269873,0.0001087233,0.0008625493,0.00001853888,0.000008107204,0.0007131572],"genre_scores_gemma":[0.950198,0.03380806,0.006522391,0.0004156028,0.001404932,0.00002581925,0.00001921731,0.00003850014,0.007567509],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2391182,"threshold_uncertainty_score":0.3524223,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1034850602293206,"score_gpt":0.4468702157781053,"score_spread":0.3433851555487847,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}