{"id":"W2066693766","doi":"10.1074/jbc.m114.574756","title":"A Genome-wide Small Interfering RNA (siRNA) Screen Reveals Nuclear Factor-κB (NF-κB)-independent Regulators of NOD2-induced Interleukin-8 (IL-8) Secretion","year":2014,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; University of Toronto; Crohn's and Colitis Foundation; National Institute of Diabetes and Digestive and Kidney Diseases; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Crohn's and Colitis Foundation of America","keywords":"NOD2; Biology; Secretion; Proinflammatory cytokine; Cell biology; Small interfering RNA; Genetics; Gene; RNA; Receptor; Immunology; Inflammation; Innate immune system; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002302124,0.0005433391,0.0004593865,0.0004693924,0.0001998219,0.000357447,0.0002405052,0.0003105415,0.001036386],"category_scores_gemma":[0.0001915493,0.0001697641,0.000396382,0.000291626,0.0001740821,0.00006741381,0.0001942354,0.000344817,0.0004844037],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002228105,"about_ca_system_score_gemma":0.0002799386,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005659449,"about_ca_topic_score_gemma":0.001968456,"domain_scores_codex":[0.9997441,0.00002407855,0.00002637552,0.00006899341,0.0001052499,0.00003120358],"domain_scores_gemma":[0.9998029,0.00006979128,0.00004986094,0.00002110741,0.0000218406,0.00003462298],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004577664,0.00001850835,0.0002211138,0.00002167621,0.00001090239,0.00008583857,0.000005587165,0.00006678353,0.9985694,0.00002108341,0.00005275611,0.0008804105],"study_design_scores_gemma":[0.0000685365,0.0004961173,0.01666048,0.00001162354,0.0001369176,0.0009131249,0.00003403445,0.002751387,0.9739202,0.00005967004,0.004929536,0.00001853374],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9765615,0.002246894,0.01047315,0.0001950795,0.00006710022,0.0001511441,0.006454135,0.0007106157,0.003140471],"genre_scores_gemma":[0.9652757,0.002180209,0.0144892,0.0004199512,0.00002382269,0.0002543194,0.01123886,0.0001982824,0.005919628],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001036386,"threshold_uncertainty_score":0.003467023,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01777576039711119,"score_gpt":0.2279467685146304,"score_spread":0.2101710081175192,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}