{"id":"W2066719210","doi":"10.1038/ni.2023","title":"An unexpected role for MHC class II","year":2011,"lang":"en","type":"letter","venue":"Nature Immunology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hôpital Saint-Luc; Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Major histocompatibility complex; Cell biology; MHC class II; MHC class I; CD74; Biology; Signal transduction; Function (biology); Antigen presentation; CD8; Intracellular; Antigen processing; Immunology; Antigen; T cell; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["research_integrity","insufficient_payload"],"category_scores_codex":[0.0003042395,0.0006876449,0.0009614998,0.0006110222,0.000592766,0.0000261802,0.001201046,0.01460122,0.001288089],"category_scores_gemma":[0.0002365309,0.0006326765,0.0003953829,0.0002020105,0.0004058435,0.0002244622,0.0001865764,0.007649532,0.0008256661],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001352994,"about_ca_system_score_gemma":0.0002647433,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007571936,"about_ca_topic_score_gemma":0.0000153935,"domain_scores_codex":[0.9965404,0.0007477368,0.0006964164,0.0008604425,0.00005935587,0.001095649],"domain_scores_gemma":[0.9973475,0.0003323301,0.0005407898,0.001349263,0.0004148645,0.00001519439],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008624877,0.00007895271,0.000004136784,0.00002740466,0.0007813285,0.00002029132,0.0004103958,1.450241e-7,0.4274292,0.0009003646,0.5659245,0.003560729],"study_design_scores_gemma":[0.001522049,0.001181884,0.0001913213,0.0000398041,0.0001721313,0.0001984458,0.00008064623,0.000001769568,0.153135,0.001040333,0.8418612,0.0005753878],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.1319428,0.2032353,0.0003462165,0.5979281,0.0389424,0.006058958,0.0009535916,0.002516632,0.01807594],"genre_scores_gemma":[0.147441,0.001203521,0.0006750665,0.6832691,0.005885787,0.001646407,0.05902391,0.0006882976,0.1001668],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.2759367,"threshold_uncertainty_score":0.9999523,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006534628546297705,"score_gpt":0.2353946527321914,"score_spread":0.2288600241858937,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}