{"id":"W2066734635","doi":"10.1096/fj.13-242750","title":"Increased sensitivity to mitochondrial permeability transition and myonuclear translocation of endonuclease G in atrophied muscle of physically active older humans","year":2013,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":205,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre; Christie (Canada); Université du Québec à Montréal","funders":"Canadian Institutes of Health Research; McGill University Health Centre; Réseau québécois de recherche sur le vieillissement","keywords":"Mitochondrial permeability transition pore; Mitochondrion; PINK1; Mitophagy; Internal medicine; Biology; Endocrinology; Oxidative stress; Skeletal muscle; Myocyte; Oxidative phosphorylation; Apoptosis; Cell biology; Autophagy; Programmed cell death; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001639172,0.0002432707,0.0002774915,0.0005889848,0.0001487138,0.0002576222,0.00008977157,0.0002757809,0.0009985636],"category_scores_gemma":[0.0001470779,0.0001544797,0.0001817562,0.000187988,0.0002133568,0.0001368037,0.0001783425,0.0002365802,0.0001665371],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000113517,"about_ca_system_score_gemma":0.00004243671,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001057642,"about_ca_topic_score_gemma":0.0005910756,"domain_scores_codex":[0.9999415,0.00000995973,0.000004126291,0.00002906359,0.000007882485,0.000007453164],"domain_scores_gemma":[0.9999344,0.000007582469,0.0000267625,0.000009237333,0.000007959631,0.00001397124],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001893795,0.0001047893,0.09153336,0.0001387497,0.0001760052,0.001426548,0.0002958761,0.0001609557,0.88621,0.00007535912,0.0002890957,0.01769536],"study_design_scores_gemma":[0.00001847544,0.000747301,0.9726749,0.00001396252,0.00007108725,0.005375876,0.0001038205,0.0003171873,0.01984066,0.00008662772,0.0007421377,0.000008011873],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977157,0.001433199,0.0004837392,0.00004303288,0.000006009442,0.000004456214,0.0001297776,0.00002037494,0.000163666],"genre_scores_gemma":[0.9986162,0.0004342571,0.0003271118,0.00006332353,0.000008044267,0.000004965846,0.000138295,0.000005792676,0.0004018486],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001057642,"threshold_uncertainty_score":0.003340483,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00758659453137408,"score_gpt":0.2198157542421994,"score_spread":0.2122291597108253,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}