{"id":"W2066760760","doi":"10.1021/bi4001326","title":"Modification of a Designed Amphipathic Cell-Penetrating Peptide and Its Effect on Solubility, Secondary Structure, and Uptake Efficiency","year":2013,"lang":"en","type":"article","venue":"Biochemistry","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Peptide; Amphiphile; Solubility; Chemistry; Chinese hamster ovary cell; Biophysics; Cytotoxicity; Cell-penetrating peptide; Protein secondary structure; Membrane; Combinatorial chemistry; Peptide sequence; Aqueous solution; Biochemistry; In vitro; Organic chemistry; Biology; Gene; Polymer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001693446,0.0001714733,0.0001426557,0.000019533,0.00008125934,0.00002931105,0.0001255149,0.0001934199,0.00002816753],"category_scores_gemma":[0.0001137644,0.0001554434,0.00004118404,0.00004195692,0.00007904058,0.00000595245,0.00007402925,0.0001325486,0.000004065964],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000077204,"about_ca_system_score_gemma":0.00005045321,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001803414,"about_ca_topic_score_gemma":0.000001683845,"domain_scores_codex":[0.9991084,0.00005764647,0.0002131139,0.000358753,0.0000961003,0.0001659568],"domain_scores_gemma":[0.9994361,0.00003219106,0.00010755,0.00026409,0.00008315769,0.00007693186],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003716445,0.00003207714,0.001012071,0.0002302752,0.00001256408,3.500199e-7,0.00004287425,0.000005609427,0.996166,0.000002482971,0.0001273347,0.002331186],"study_design_scores_gemma":[0.0003377527,0.0006168211,0.009985632,0.00003480661,0.00001296495,0.000009467131,0.00006407446,0.0001997432,0.9885411,0.00003716121,0.000009979869,0.000150542],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979789,0.00105991,0.00004194242,0.00001117792,0.00003191433,0.000212182,0.00002502772,0.000007918602,0.000631081],"genre_scores_gemma":[0.9994165,0.00005374267,0.0001139061,0.00005230743,0.00005936439,0.0000210523,0.00006323447,0.00001233348,0.0002075622],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008973561,"threshold_uncertainty_score":0.6338797,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01084099479653368,"score_gpt":0.2371437749364423,"score_spread":0.2263027801399086,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}