{"id":"W2066814636","doi":"10.1073/pnas.0605301104","title":"Aldolase provides an unusual binding site for thrombospondin-related anonymous protein in the invasion machinery of the malaria parasite","year":2007,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Malaria Research and Control","field":"Medicine","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium","funders":"National Institute of General Medical Sciences; National Institutes of Health","keywords":"Aldolase A; Biology; Plasmodium falciparum; Biochemistry; Isomerase; Biophysics; Transmembrane protein; Protein structure; Plasmodium vivax; Plasmodium (life cycle); Fructose-bisphosphate aldolase; Cell biology; Parasite hosting; Enzyme; Malaria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007189787,0.0001123229,0.000218748,0.0002886449,0.0002389255,0.00002740756,0.000828482,0.0001182236,0.000009866161],"category_scores_gemma":[0.002115135,0.00005167689,0.0001177463,0.001295252,0.0007228742,0.0003990116,0.0001055547,0.0003609419,5.912689e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004395877,"about_ca_system_score_gemma":0.0001269351,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004222282,"about_ca_topic_score_gemma":0.000003088569,"domain_scores_codex":[0.9974191,0.00003220792,0.0004860843,0.0002424129,0.001544766,0.0002754057],"domain_scores_gemma":[0.9988273,0.0003274904,0.0004683475,0.00002508649,0.000300638,0.00005118306],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003644079,0.0001657328,0.04198847,0.0001473346,0.00002039375,5.465318e-8,0.0005105235,0.00001115809,0.9064153,0.04983941,0.00009031754,0.0004468688],"study_design_scores_gemma":[0.001266377,0.0004068617,0.630375,0.0003455226,0.00003549676,0.00002133965,0.0004936029,0.002826774,0.3476542,0.01644423,0.00005076556,0.00007979757],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9847236,0.0000707274,0.000002574631,0.01209495,0.00001326221,0.00178743,0.000025336,0.000007055729,0.001275079],"genre_scores_gemma":[0.9987956,0.000004621808,0.0006235209,0.0002556301,0.00005816969,0.00004299256,9.168054e-7,0.000005784132,0.0002127848],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5883865,"threshold_uncertainty_score":0.266346,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04668013640127432,"score_gpt":0.3489803779418056,"score_spread":0.3023002415405313,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}