{"id":"W2066829203","doi":"10.1074/jbc.275.2.1439","title":"BNIP3 Heterodimerizes with Bcl-2/Bcl-XL and Induces Cell Death Independent of a Bcl-2 Homology 3 (BH3) Domain at Both Mitochondrial and Nonmitochondrial Sites","year":2000,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":350,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Biological Sciences; University of Manitoba","funders":"","keywords":"Bcl-xL; Mitochondrion; Programmed cell death; Biology; Homology (biology); Cell biology; Mitochondrial DNA; Domain (mathematical analysis); Genetics; Molecular biology; Biophysics; Apoptosis; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001632738,0.0002535068,0.000431932,0.00002929952,0.00009148935,0.00002499137,0.0001656112,0.0005154753,0.0002043956],"category_scores_gemma":[0.00002847288,0.0001633063,0.0001248859,0.00004851677,0.0002567204,0.000008517516,0.0001062942,0.0002167217,9.18483e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000192813,"about_ca_system_score_gemma":0.00004887229,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006866386,"about_ca_topic_score_gemma":0.000004673443,"domain_scores_codex":[0.9986339,0.00007988081,0.0004807783,0.0003657679,0.0001886768,0.0002509959],"domain_scores_gemma":[0.9991366,0.00003992168,0.0003905314,0.0001803881,0.00007782934,0.0001747065],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001646869,0.0001436327,0.002197414,0.00003761632,0.00007498857,0.00003281298,0.00004884858,0.00002047425,0.994313,0.000003521242,0.0001151575,0.001365675],"study_design_scores_gemma":[0.003212667,0.001958676,0.0046946,0.00004357431,0.00006253352,0.0008474129,0.00009619032,0.00001044561,0.9846272,0.0001835565,0.003971823,0.0002912572],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964196,0.002666127,0.0001155875,0.00006250945,0.00009564939,0.0001268609,0.00002091617,0.000004808743,0.0004879512],"genre_scores_gemma":[0.9939417,0.001694572,0.002889597,0.00004540793,0.0005981165,0.000004779202,0.00004381711,0.00001490608,0.00076712],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009685726,"threshold_uncertainty_score":0.6659437,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01021644366327814,"score_gpt":0.2157770759322543,"score_spread":0.2055606322689761,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}