{"id":"W2066831189","doi":"10.3899/jrheum.150036","title":"Intestinal Dysbiosis and Potential Consequences of Microbiome-altering Antibiotic Use in the Pathogenesis of Human Rheumatic Disease","year":2015,"lang":"en","type":"letter","venue":"The Journal of Rheumatology","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","keywords":"Medicine; Ankylosing spondylitis; Disease; Immunology; Human leukocyte antigen; Microbiome; Dysbiosis; Rheumatoid arthritis; Autoimmune disease; Allele; Epigenetics; Reactive arthritis; Genetics; Bioinformatics; Arthritis; Biology; Gut flora; Gene; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001090608,0.0002799138,0.0007429998,0.000391856,0.0008825058,0.0009026096,0.0004668391,0.006989517,0.001483554],"category_scores_gemma":[0.005047092,0.0001981521,0.0003807338,0.0003944434,0.001461048,0.001054695,0.0004983831,0.004700232,0.0008317996],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001288298,"about_ca_system_score_gemma":0.0006872755,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001077401,"about_ca_topic_score_gemma":0.001827785,"domain_scores_codex":[0.9994192,0.0003176868,0.00005350984,0.00005413631,0.00009105769,0.00006450057],"domain_scores_gemma":[0.9981345,0.001263162,0.0001889412,0.0000741749,0.0001703738,0.0001687478],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002985767,0.0007195403,0.1128414,0.001188163,0.0003257723,0.2745415,0.002074659,0.0009693278,0.007004337,0.01907374,0.409151,0.1691249],"study_design_scores_gemma":[0.001453152,0.001542522,0.1058147,0.002442255,0.0005279344,0.4298351,0.003261177,0.007134377,0.003298905,0.05780894,0.3866815,0.0001994711],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.07744528,0.05023111,0.0006148046,0.8523918,0.007403903,0.00003633574,0.00009796159,0.00006885967,0.01170992],"genre_scores_gemma":[0.5923213,0.03720894,0.001177285,0.2879192,0.07604975,0.0000484806,0.00006500092,0.00002516095,0.005184787],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.006989517,"threshold_uncertainty_score":0.00934726,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03347831392962877,"score_gpt":0.2842962570980151,"score_spread":0.2508179431683863,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}