{"id":"W2066837478","doi":"10.1021/jm701450q","title":"Second-Generation Aspirin and Indomethacin Prodrugs Possessing an<i>O</i><sup>2</sup>-(Acetoxymethyl)-1-(2-carboxypyrrolidin-1-yl)diazenium-1,2-diolate Nitric Oxide Donor Moiety: Design, Synthesis, Biological Evaluation, and Nitric Oxide Release Studies","year":2008,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Cancer Institute; National Institutes of Health","keywords":"Prodrug; Chemistry; Aspirin; Moiety; Ulcer index; Nitric oxide; Stereochemistry; Organic chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.005746177,0.0005286638,0.001324737,0.0003630058,0.0003497,0.00004308206,0.0001750508,0.0004285573,0.00008065654],"category_scores_gemma":[0.006058047,0.0003854402,0.0001751606,0.0004938772,0.0004583038,0.0004538927,0.00007516646,0.001111918,0.000003017767],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003237558,"about_ca_system_score_gemma":0.0008226926,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008310237,"about_ca_topic_score_gemma":6.274203e-7,"domain_scores_codex":[0.9957317,0.0007011438,0.001297525,0.0005629313,0.001184527,0.0005222331],"domain_scores_gemma":[0.9957024,0.001117057,0.0009232644,0.0003417103,0.001125493,0.0007900164],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001280194,0.0002259216,0.02040776,0.0008912867,0.0004272462,0.0009538268,0.000662028,0.0001712218,0.9692996,0.000001115692,0.0007883667,0.004891424],"study_design_scores_gemma":[0.008636669,0.0008949232,0.03936227,0.001201269,0.00163597,0.01585351,0.002061211,0.005306344,0.9237974,0.0001040102,0.0004061891,0.0007402718],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9671547,0.03168372,0.0001610586,0.0002236971,0.00007887682,0.0005726184,0.000005683633,0.00003883401,0.00008084754],"genre_scores_gemma":[0.9893197,0.006022195,0.002529912,0.0003680712,0.001555199,0.00005391662,0.00001461815,0.00004996337,0.00008646608],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04550225,"threshold_uncertainty_score":0.9998598,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07937257965475587,"score_gpt":0.3161948935891979,"score_spread":0.2368223139344421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}