{"id":"W2066837478","doi":"10.1021/jm701450q","title":"Second-Generation Aspirin and Indomethacin Prodrugs Possessing an<i>O</i><sup>2</sup>-(Acetoxymethyl)-1-(2-carboxypyrrolidin-1-yl)diazenium-1,2-diolate Nitric Oxide Donor Moiety: Design, Synthesis, Biological Evaluation, and Nitric Oxide Release Studies","year":2008,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Cancer Institute; National Institutes of Health","keywords":"Prodrug; Chemistry; Aspirin; Moiety; Ulcer index; Nitric oxide; Stereochemistry; Organic chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009843319,0.0002832219,0.0002120913,0.00009181887,0.00006844982,0.0001130525,0.0002062503,0.0002488291,0.0004215635],"category_scores_gemma":[0.00007528898,0.00009836543,0.0001645368,0.00007680317,0.0001169616,0.0001634354,0.00007947625,0.0001960396,0.0001689634],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001866036,"about_ca_system_score_gemma":0.0000953999,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002049424,"about_ca_topic_score_gemma":0.0003479487,"domain_scores_codex":[0.9999431,0.000008452348,0.000004891928,0.00001261334,0.00001703495,0.00001391545],"domain_scores_gemma":[0.9999567,0.000004532634,0.00001597087,0.000003901786,0.000006929096,0.00001190734],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009024374,0.00003713701,0.00008671897,0.00003963629,0.000003572339,0.00004423705,0.000009774211,0.000115143,0.9975365,0.00006448187,0.00001419018,0.001958238],"study_design_scores_gemma":[0.00003639463,0.00164643,0.001348277,0.000002376279,0.00001469859,0.0002687748,0.000008686871,0.0003344043,0.9945847,0.00001415999,0.001737054,0.000004033064],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928161,0.002262101,0.003650889,0.00003487253,0.00002180653,0.00007136637,0.00008305134,0.0000261719,0.001033735],"genre_scores_gemma":[0.9903562,0.001138282,0.006079413,0.00003531614,0.00001186413,0.00006537537,0.0001935863,0.000005302579,0.002114772],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004215635,"threshold_uncertainty_score":0.001410246,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07937257965475587,"score_gpt":0.3161948935891979,"score_spread":0.2368223139344421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}