{"id":"W2066939817","doi":"10.1074/jbc.m610314200","title":"NIPA1(SPG6), the Basis for Autosomal Dominant Form of Hereditary Spastic Paraplegia, Encodes a Functional Mg2+ Transporter","year":2006,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Hereditary Neurological Disorders","field":"Neuroscience","cited_by":141,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Hereditary spastic paraplegia; Endosome; Cell biology; Mutant; Biology; Transfection; Gene; Chemistry; Molecular biology; Phenotype; Biochemistry; Intracellular","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001137177,0.001482804,0.0003551216,0.0005034335,0.0002670598,0.0002145761,0.0005961757,0.0006369872,0.002855575],"category_scores_gemma":[0.0002449494,0.0001628171,0.0003519222,0.0003301584,0.0004549396,0.0001632037,0.0005402446,0.0007134842,0.001345325],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002722771,"about_ca_system_score_gemma":0.0003096086,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003763916,"about_ca_topic_score_gemma":0.0003821742,"domain_scores_codex":[0.9998916,0.00001392863,0.00001038218,0.00003022339,0.00004376988,0.00001010649],"domain_scores_gemma":[0.9998511,0.00002198686,0.00006084011,0.000008722896,0.00001131752,0.00004610854],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002062047,0.0000646379,0.004250333,0.0002376323,0.00005557758,0.01142545,0.0000601543,0.000310969,0.9597993,0.0009096079,0.0009701822,0.02170989],"study_design_scores_gemma":[0.0002633926,0.001043297,0.1464721,0.000236186,0.0002589591,0.235134,0.0001926716,0.008696984,0.5351427,0.00272939,0.06975459,0.00007581252],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9745,0.004581254,0.01124854,0.0009703668,0.0002135616,0.0001165051,0.002862585,0.0009263665,0.004580894],"genre_scores_gemma":[0.9812584,0.00256952,0.006521191,0.0002172259,0.0000579597,0.00007937534,0.003417094,0.00006998091,0.00580934],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002855575,"threshold_uncertainty_score":0.009552836,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03633604833662743,"score_gpt":0.2404263144947423,"score_spread":0.2040902661581148,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}