{"id":"W2066948394","doi":"10.1038/ncomms2629","title":"Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer","year":2013,"lang":"en","type":"article","venue":"Nature Communications","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":169,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Ontario; Vancouver General Hospital; Mount Sinai Hospital; Genome Canada; Alberta Health Services; Women's College Hospital; University of Toronto; BC Cancer Agency; Calgary Laboratory Services; University of Calgary","funders":"National Center for Research Resources; National Institute of General Medical Sciences; Canadian Institutes of Health Research; European Commission; National Cancer Institute; National Institutes of Health; Cancer Research UK; Wellcome Trust; Roswell Park Cancer Institute; Ovarian Cancer Research Fund","keywords":"HNF1B; Ovarian cancer; Epigenetics; Serous fluid; DNA methylation; Biology; Cancer research; Cancer; Clear cell; Methylation; Genetics; Gene; Promoter; Gene expression; Carcinoma","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002176322,0.0001296594,0.0001766538,0.0005159486,0.0001690846,0.0002399423,0.0001204248,0.0002237871,0.001537345],"category_scores_gemma":[0.0004196215,0.0001252065,0.0002756846,0.0003913337,0.0001112208,0.00007732242,0.0001710842,0.0002754295,0.000209559],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002557915,"about_ca_system_score_gemma":0.0001530108,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004735769,"about_ca_topic_score_gemma":0.008124881,"domain_scores_codex":[0.9998918,0.00001145845,0.000004740959,0.00004250686,0.00003331013,0.00001620425],"domain_scores_gemma":[0.9998565,0.0000293343,0.00005245909,0.00001801236,0.00002610117,0.00001759007],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005039467,0.00005027277,0.3681897,0.00008797998,0.0002306985,0.0005399516,0.0002155848,0.0004439703,0.5603266,0.000453636,0.001047426,0.06791023],"study_design_scores_gemma":[0.00002222261,0.0001246255,0.9301837,0.0000145271,0.0001718434,0.001618417,0.0001598436,0.001375936,0.06051013,0.0006698005,0.005135884,0.00001300084],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922717,0.001576782,0.003577062,0.0003158169,0.00002423674,0.00001592815,0.0006885529,0.00007058706,0.001459491],"genre_scores_gemma":[0.9935473,0.0009634276,0.002584598,0.0002057435,0.0000236774,0.00001117141,0.0005349135,0.00001575838,0.002113438],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004735769,"threshold_uncertainty_score":0.009416401,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0219077219180144,"score_gpt":0.3309310404306857,"score_spread":0.3090233185126713,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}