{"id":"W2066948394","doi":"10.1038/ncomms2629","title":"Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer","year":2013,"lang":"en","type":"article","venue":"Nature Communications","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":169,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Ontario; Vancouver General Hospital; Mount Sinai Hospital; Genome Canada; Alberta Health Services; Women's College Hospital; University of Toronto; BC Cancer Agency; Calgary Laboratory Services; University of Calgary","funders":"National Center for Research Resources; National Institute of General Medical Sciences; Canadian Institutes of Health Research; European Commission; National Cancer Institute; National Institutes of Health; Cancer Research UK; Wellcome Trust; Roswell Park Cancer Institute; Ovarian Cancer Research Fund","keywords":"HNF1B; Ovarian cancer; Epigenetics; Serous fluid; DNA methylation; Biology; Cancer research; Cancer; Clear cell; Methylation; Genetics; Gene; Promoter; Gene expression; Carcinoma","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003561556,0.0001228329,0.0001818674,0.0001468271,0.0001516293,0.00003490597,0.0006808994,0.0002839525,0.00005363406],"category_scores_gemma":[0.0002287046,0.0001267813,0.0001756213,0.000574015,0.00008221315,0.000006043512,0.0001671003,0.0001453521,0.00001644577],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000317919,"about_ca_system_score_gemma":0.00007641062,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000198667,"about_ca_topic_score_gemma":0.001728129,"domain_scores_codex":[0.9988549,0.0001121753,0.000410566,0.0003310424,0.0001287574,0.0001625192],"domain_scores_gemma":[0.9968367,0.00006597579,0.0001995316,0.002058871,0.0007527965,0.00008616463],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001752904,0.00009129105,0.02298298,0.000008060018,0.0001347754,1.165381e-8,0.00008191916,0.0005364167,0.9718477,0.0006149216,0.0004546246,0.003229735],"study_design_scores_gemma":[0.000203043,0.00009404146,0.2827139,0.000004037635,0.000170797,1.478216e-7,0.00003531569,0.0004617827,0.6949437,0.0006384982,0.02056017,0.0001745341],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9616598,0.01391335,0.02121036,0.001831801,0.0001172559,0.0008738943,0.0001392871,0.00001188026,0.0002423268],"genre_scores_gemma":[0.9842755,0.002135827,0.01181139,0.0001198209,0.00007234114,0.0003866874,0.000848141,0.00001854148,0.0003317837],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2769041,"threshold_uncertainty_score":0.5169991,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0219077219180144,"score_gpt":0.3309310404306857,"score_spread":0.3090233185126713,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}