{"id":"W2066948522","doi":"10.3390/v5020654","title":"Low Copper and High Manganese Levels in Prion Protein Plaques","year":2013,"lang":"en","type":"article","venue":"Viruses","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Division of Materials Research; National Institute of Neurological Disorders and Stroke; Division of Chemistry; U.S. Department of Defense; National Science Foundation","keywords":"Manganese; Hamster; Copper; Neurodegeneration; Prion protein; Chemistry; Pathology; Transmissible spongiform encephalopathy; Biology; Mesocricetus; Virology; Molecular biology; Scrapie; Medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001717349,0.0003463053,0.0002329468,0.0008153718,0.0002695899,0.0003915199,0.0001576702,0.0002924998,0.0007897309],"category_scores_gemma":[0.000184268,0.0002756773,0.0001060155,0.0002256927,0.0004486764,0.0002703938,0.0003701118,0.0002809024,0.0002190144],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002003901,"about_ca_system_score_gemma":0.0001397011,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006697716,"about_ca_topic_score_gemma":0.0007185538,"domain_scores_codex":[0.9998844,0.00001547354,0.00001326189,0.00003920528,0.00002718243,0.00002051618],"domain_scores_gemma":[0.9998499,0.00001869222,0.00004283306,0.00001557124,0.00003390433,0.00003915785],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001047459,0.000009097614,0.001626108,0.00003350141,0.0000116263,0.0001199762,0.00006493198,0.00002622474,0.9973997,0.0000904968,0.00001412755,0.0004995082],"study_design_scores_gemma":[0.00003295328,0.0003848622,0.1544593,0.00002856927,0.0001013214,0.002297897,0.0002848726,0.001050949,0.8386526,0.0008655686,0.001823938,0.00001716072],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968081,0.0009219405,0.001255167,0.00002038036,0.000006946676,0.000007297161,0.0001255859,0.00003230596,0.0008223489],"genre_scores_gemma":[0.9966641,0.0003361249,0.001133102,0.00001275301,0.00000420078,0.00001207215,0.0002027244,0.00001392602,0.001621076],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008153718,"threshold_uncertainty_score":0.002641916,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01387426287989468,"score_gpt":0.2503987544186681,"score_spread":0.2365244915387734,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}