{"id":"W2066948522","doi":"10.3390/v5020654","title":"Low Copper and High Manganese Levels in Prion Protein Plaques","year":2013,"lang":"en","type":"article","venue":"Viruses","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Division of Materials Research; National Institute of Neurological Disorders and Stroke; Division of Chemistry; U.S. Department of Defense; National Science Foundation","keywords":"Manganese; Hamster; Copper; Neurodegeneration; Prion protein; Chemistry; Pathology; Transmissible spongiform encephalopathy; Biology; Mesocricetus; Virology; Molecular biology; Scrapie; Medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006004822,0.00009610659,0.00008181472,0.00003162915,0.00003465269,0.00004031773,0.00007663611,0.00008188401,0.0001140995],"category_scores_gemma":[0.00004923094,0.00008440621,0.00002117786,0.00003797418,0.00003687566,0.00001044814,0.00008070048,0.00004393822,0.00003344079],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006027399,"about_ca_system_score_gemma":0.00002197821,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003105334,"about_ca_topic_score_gemma":0.00003882013,"domain_scores_codex":[0.9994401,0.00003781044,0.0001085919,0.0002026699,0.00006002701,0.0001507949],"domain_scores_gemma":[0.9997316,0.000005644698,0.00003093269,0.0001494704,0.00002191043,0.00006042564],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002426631,0.00003184682,0.004769166,0.00002907862,0.00000808089,0.000002801869,0.00001808452,0.000003134169,0.9684666,0.00008582238,0.0005208006,0.02604028],"study_design_scores_gemma":[0.0004340794,0.0001127596,0.05269009,0.00006101006,0.00000318959,0.000003065077,0.00003135078,0.00001483201,0.9366959,0.0004876287,0.009287262,0.0001788653],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953614,0.004016366,0.00003382659,0.0001254118,0.00002385718,0.0003551506,0.00001453561,0.00001162653,0.00005775023],"genre_scores_gemma":[0.998316,0.0004961023,0.0003728007,0.000513408,0.00007406864,0.00009671733,0.00001159261,0.00001282541,0.0001064772],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04792092,"threshold_uncertainty_score":0.3441985,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01387426287989468,"score_gpt":0.2503987544186681,"score_spread":0.2365244915387734,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}