{"id":"W2066996579","doi":"10.1089/cell.2013.0018","title":"Effect of Histone Deacetylase Inhibitor Valproic Acid Treatment on Donor Cell Growth Characteristics, Cell Cycle Arrest, Apoptosis, and Handmade Cloned Bovine Embryo Production Efficiency","year":2013,"lang":"en","type":"article","venue":"Cellular Reprogramming","topic":"Reproductive Biology and Fertility","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Canadian Institutes of Health Research","keywords":"Somatic cell nuclear transfer; Biology; Histone deacetylase inhibitor; Trichostatin A; Blastocyst; Molecular biology; Apoptosis; Embryo; Cell cycle; Terminal deoxynucleotidyl transferase; Histone deacetylase; Andrology; TUNEL assay; Histone; Embryogenesis; Cell biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001763467,0.0003228124,0.0004961284,0.0001901154,0.0001268336,0.0003154363,0.0002085619,0.0001938537,0.0008274399],"category_scores_gemma":[0.000168261,0.0001150097,0.0002703521,0.0001297188,0.0001433182,0.0001625939,0.0001589002,0.0004708592,0.0001923999],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003166919,"about_ca_system_score_gemma":0.0002641517,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001202875,"about_ca_topic_score_gemma":0.001693754,"domain_scores_codex":[0.9997823,0.00003534285,0.00003232645,0.00006306761,0.000054472,0.00003257185],"domain_scores_gemma":[0.9998374,0.00004448949,0.00004040779,0.0000194363,0.0000240336,0.00003418256],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002471581,0.00004155324,0.0004042221,0.00005446679,0.00001063597,0.00004637067,0.0000206237,0.00006774708,0.9967271,0.00002076889,0.00002967474,0.0023297],"study_design_scores_gemma":[0.00001489992,0.0007201697,0.004446953,0.000005252363,0.00003067669,0.0001146523,0.00002202839,0.0003563497,0.9927956,0.00001061439,0.001477859,0.000004916337],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895654,0.007269682,0.001263616,0.00006780723,0.00006632687,0.00002903867,0.0004070634,0.00005233154,0.001278854],"genre_scores_gemma":[0.993498,0.002294488,0.001786447,0.00005161341,0.00001325019,0.0000318203,0.0006383862,0.00002080122,0.001665178],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001202875,"threshold_uncertainty_score":0.00276804,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00747844937242902,"score_gpt":0.250615436253648,"score_spread":0.243136986881219,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}