{"id":"W2066996579","doi":"10.1089/cell.2013.0018","title":"Effect of Histone Deacetylase Inhibitor Valproic Acid Treatment on Donor Cell Growth Characteristics, Cell Cycle Arrest, Apoptosis, and Handmade Cloned Bovine Embryo Production Efficiency","year":2013,"lang":"en","type":"article","venue":"Cellular Reprogramming","topic":"Reproductive Biology and Fertility","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Canadian Institutes of Health Research","keywords":"Somatic cell nuclear transfer; Biology; Histone deacetylase inhibitor; Trichostatin A; Blastocyst; Molecular biology; Apoptosis; Embryo; Cell cycle; Terminal deoxynucleotidyl transferase; Histone deacetylase; Andrology; TUNEL assay; Histone; Embryogenesis; Cell biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000757692,0.0004228845,0.000746958,0.0001466125,0.0002123833,0.00002869818,0.00009542311,0.0002194571,0.00002962717],"category_scores_gemma":[0.0004232694,0.000315753,0.0001952938,0.0002204947,0.0003683817,0.0001074239,0.00005990746,0.0002802055,0.0000506218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001967876,"about_ca_system_score_gemma":0.00005232138,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001760817,"about_ca_topic_score_gemma":6.915858e-7,"domain_scores_codex":[0.9972669,0.0002734436,0.0005667494,0.001190566,0.000228093,0.000474234],"domain_scores_gemma":[0.9982939,0.00008738165,0.0003336316,0.0008658489,0.0001816686,0.0002376089],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002818068,0.001580289,0.009047043,0.000865889,0.00005311177,0.00001300219,0.0003175739,6.220875e-7,0.9461666,0.000002986359,0.00004371133,0.03909105],"study_design_scores_gemma":[0.002030692,0.007497136,0.01539874,0.0001011919,0.0002932285,0.00001191515,0.00004906788,0.00006526473,0.9740744,0.00001184995,0.0002172262,0.0002493121],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937221,0.002203526,0.0001909024,0.0002393467,0.0006764303,0.002648721,0.000004916227,0.0001241889,0.0001898427],"genre_scores_gemma":[0.9976127,0.0001267987,0.000469824,0.00001743382,0.0005095589,0.0002763613,0.0001130893,0.00004478572,0.0008294432],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03884174,"threshold_uncertainty_score":0.9999294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00747844937242902,"score_gpt":0.250615436253648,"score_spread":0.243136986881219,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}