{"id":"W2067002798","doi":"10.1016/j.bcp.2007.02.005","title":"Modulation of GSH levels in ABCC1 expressing tumor cells triggers apoptosis through oxidative stress","year":2007,"lang":"en","type":"article","venue":"Biochemical Pharmacology","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":72,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"McGill University","keywords":"ABCC1; Glutathione; Oxidative stress; Apigenin; Reactive oxygen species; Apoptosis; Biology; Chemistry; Pharmacology; Cell biology; Biochemistry; Antioxidant; ATP-binding cassette transporter; Enzyme; Flavonoid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000158834,0.0002029415,0.0004137286,0.0002453337,0.0002373685,0.000351375,0.0001603338,0.0003474955,0.001503566],"category_scores_gemma":[0.0001622638,0.0001452829,0.0001897681,0.0002647811,0.0002178479,0.0002496944,0.0001532267,0.0007795934,0.0003000165],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004600611,"about_ca_system_score_gemma":0.0002102023,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006594754,"about_ca_topic_score_gemma":0.001008177,"domain_scores_codex":[0.9998158,0.00004387819,0.0000147943,0.00002138658,0.00004620488,0.00005798537],"domain_scores_gemma":[0.9998966,0.0000284486,0.00002165536,0.00001789712,0.00001807069,0.0000171292],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005261446,0.00004607922,0.0003980064,0.00003342897,0.000009646568,0.0001133736,0.0000303978,0.00006565093,0.996565,0.0001930702,0.0001072332,0.001911868],"study_design_scores_gemma":[0.00002478369,0.0003354471,0.002420747,0.000002661351,0.0000116072,0.0002257369,0.000043147,0.0005874498,0.9953179,0.00007226776,0.0009552094,0.00000307052],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963995,0.001111329,0.001046688,0.0003074851,0.00003886507,0.00001682502,0.0001740793,0.00006389953,0.0008412714],"genre_scores_gemma":[0.9984455,0.0002814734,0.0003759405,0.00004034657,0.000008202305,0.000012023,0.0001583015,0.000006060698,0.0006721274],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001503566,"threshold_uncertainty_score":0.005029917,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02794938590093433,"score_gpt":0.3244915452988799,"score_spread":0.2965421593979455,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}