{"id":"W2067020827","doi":"10.1038/cddis.2012.61","title":"Apoptosis, autophagy and ER stress in mevalonate cascade inhibition-induced cell death of human atrial fibroblasts","year":2012,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":123,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital Research Institute of Manitoba; University of Manitoba","funders":"Canadian Institutes of Health Research; Manitoba Health Research Council; Natural Sciences and Engineering Research Council of Canada; GlaxoSmithKline","keywords":"Autophagy; Unfolded protein response; Cell biology; Programmed cell death; Apoptosis; Endoplasmic reticulum; Chemistry; Simvastatin; Protein kinase A; Biology; Kinase; Pharmacology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001183534,0.0002357875,0.000344536,0.0001485942,0.00008824968,0.00001746178,0.00004771048,0.0001150417,0.0001494601],"category_scores_gemma":[0.00002949638,0.0002082559,0.000131455,0.00009289829,0.00005959191,0.0002046315,0.00005520196,0.0001430454,0.000008762931],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003074409,"about_ca_system_score_gemma":0.0001193733,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001042826,"about_ca_topic_score_gemma":0.000001974541,"domain_scores_codex":[0.9987016,0.00006711874,0.0003174577,0.0002980294,0.0002258296,0.0003899811],"domain_scores_gemma":[0.9984702,0.00005327695,0.0001028129,0.0002533846,0.00003878222,0.001081579],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003503447,0.003306451,0.6110281,0.002734403,0.0001446225,0.0002984208,0.001557005,0.00001551772,0.371543,0.004114418,0.0004241247,0.001330552],"study_design_scores_gemma":[0.01034197,0.000373116,0.5046615,0.0002717672,0.0005195265,0.000006096027,0.000131315,0.0001432853,0.4814532,0.001598672,0.0001128685,0.0003867048],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906538,0.007285295,0.000006165709,0.00004866314,0.00009370399,0.0004411153,0.00009687072,0.00003715464,0.001337258],"genre_scores_gemma":[0.9986143,0.0003102317,0.00005368603,0.0002442106,0.0002912346,0.00001904176,0.0001142115,0.0000292486,0.0003238338],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1099102,"threshold_uncertainty_score":0.849243,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01873914112987106,"score_gpt":0.278854087699053,"score_spread":0.2601149465691819,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}