{"id":"W2067026554","doi":"10.1016/j.molimm.2006.02.003","title":"AID mutates a non-immunoglobulin transgene independent of chromosomal position","year":2006,"lang":"en","type":"article","venue":"Molecular Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"National Institute on Aging","keywords":"Somatic hypermutation; Cytidine deaminase; Biology; Activation-induced (cytidine) deaminase; Provirus; Enhancer; Genetics; Mutation; Gene; Transgene; Molecular biology; Immunoglobulin class switching; Mutation rate; Affinity maturation; Antibody; B cell; Gene expression; Genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000391504,0.001147184,0.0005181807,0.001429008,0.0004285678,0.0007486091,0.001085702,0.001185287,0.006943483],"category_scores_gemma":[0.0003117854,0.0005285764,0.000537006,0.0004857683,0.001368586,0.0003258593,0.0008235839,0.002255789,0.001753183],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006600816,"about_ca_system_score_gemma":0.0004630275,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000677311,"about_ca_topic_score_gemma":0.001221383,"domain_scores_codex":[0.9994382,0.00008062587,0.00006337469,0.0001347109,0.0001519194,0.0001311028],"domain_scores_gemma":[0.9992115,0.0002927134,0.0001725989,0.0001190444,0.00003092485,0.0001730432],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002096223,0.00006420564,0.0001417252,0.00004073503,0.00001287211,0.0002179918,0.00002059028,0.00008658587,0.9967667,0.0009579476,0.00008614308,0.001394919],"study_design_scores_gemma":[0.00005514834,0.0001099088,0.000911143,0.000006564006,0.00003311576,0.0004476148,0.00003475331,0.0007166103,0.9934592,0.0001123844,0.004105175,0.000008320081],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9695939,0.0007580906,0.01685008,0.0003834827,0.0004433099,0.0001624176,0.001446353,0.001511076,0.008851317],"genre_scores_gemma":[0.9848601,0.0002873099,0.005812927,0.00009238536,0.00004173422,0.00005815125,0.0005994259,0.000328856,0.007919113],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006943483,"threshold_uncertainty_score":0.02322829,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003868613756517632,"score_gpt":0.1952670566939906,"score_spread":0.1913984429374729,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}