{"id":"W2067026554","doi":"10.1016/j.molimm.2006.02.003","title":"AID mutates a non-immunoglobulin transgene independent of chromosomal position","year":2006,"lang":"en","type":"article","venue":"Molecular Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"National Institute on Aging","keywords":"Somatic hypermutation; Cytidine deaminase; Biology; Activation-induced (cytidine) deaminase; Provirus; Enhancer; Genetics; Mutation; Gene; Transgene; Molecular biology; Immunoglobulin class switching; Mutation rate; Affinity maturation; Antibody; B cell; Gene expression; Genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0002141166,0.0004697541,0.0007816689,0.0003454762,0.000215476,0.00001604189,0.0006457521,0.000917614,0.0009806865],"category_scores_gemma":[0.00002048343,0.0004679666,0.0003608432,0.0003310607,0.0008606697,0.000105045,0.0001904481,0.0006411808,0.0008495747],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009217985,"about_ca_system_score_gemma":0.0001315421,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001180817,"about_ca_topic_score_gemma":0.00005079333,"domain_scores_codex":[0.9970992,0.0004113163,0.0009068254,0.0006290842,0.00008506014,0.0008685235],"domain_scores_gemma":[0.9986345,0.00008208576,0.0003517402,0.000738863,0.0001723618,0.00002050557],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005364536,0.0007195859,0.0005336217,0.00002850651,0.0006469918,0.000149898,0.0001661978,0.00007622362,0.9931504,0.002260497,0.0002744287,0.001457271],"study_design_scores_gemma":[0.004593824,0.0009348643,0.004787886,0.0000405319,0.0001474717,0.0009037533,0.0001253023,0.000005762816,0.9805638,0.001156831,0.006302014,0.0004379662],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9746012,0.01824923,0.002478938,0.0003692928,0.001033571,0.0004417519,0.00005867219,0.0001404068,0.002626934],"genre_scores_gemma":[0.9972299,0.0001517318,0.0003149479,0.0001390864,0.00003161856,0.00006889988,0.000717549,0.00005844249,0.001287867],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02262865,"threshold_uncertainty_score":0.9999325,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003868613756517632,"score_gpt":0.1952670566939906,"score_spread":0.1913984429374729,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}