{"id":"W2067034947","doi":"10.1002/adsc.200404032","title":"Asymmetric Dihydroxylation of Cinnamonitrile to <i>trans</i>‐3‐[(5<i>S</i>,6<i>R</i>)‐5,6‐Dihydroxycyclohexa‐1,3‐dienyl]‐acrylonitrile using Chlorobenzene Dioxygenase in <i>Escherichia coli</i> (pTEZ30)","year":2004,"lang":"en","type":"article","venue":"Advanced Synthesis & Catalysis","topic":"Enzyme Catalysis and Immobilization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Brock University","funders":"Natural Sciences and Engineering Research Council of Canada; Brock University","keywords":"Dihydroxylation; Chemistry; Chlorobenzene; Escherichia coli; Dioxygenase; Stereochemistry; Acrylonitrile; Cofactor; Substrate (aquarium); Enantiomeric excess; Dehydrogenase; Fluorobenzene; Yield (engineering); Biotransformation; Enzyme; Enantioselective synthesis; Catalysis; Organic chemistry; Biochemistry; Benzene; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005737043,0.0005000179,0.0008083041,0.0006954471,0.0001566232,0.00003672939,0.000496554,0.0002803123,0.00002006443],"category_scores_gemma":[0.0006885235,0.0005372795,0.0004029336,0.003140626,0.00009758818,0.0000723859,0.0001528196,0.0001657557,0.00001205183],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002096147,"about_ca_system_score_gemma":0.0001669014,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004418387,"about_ca_topic_score_gemma":0.0004342521,"domain_scores_codex":[0.9966992,0.0001355266,0.001036362,0.001017191,0.0004722279,0.0006394559],"domain_scores_gemma":[0.9979036,0.00009795614,0.0004141548,0.001092231,0.0002437606,0.0002483319],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001901467,0.000361262,0.0007265891,0.0000499845,0.0001139796,0.000005014448,0.0001193195,0.1230699,0.8729521,0.00001701832,0.00001863935,0.002376079],"study_design_scores_gemma":[0.001051419,0.000193346,0.001296156,0.0001174471,0.0002046384,0.000006286466,0.0001265322,0.0003798011,0.992977,0.00006739237,0.002989413,0.0005905591],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9684398,0.00200601,0.02826479,0.00008514478,0.0001173728,0.000608041,0.0001097722,0.00003651586,0.0003325842],"genre_scores_gemma":[0.9910727,0.0006563622,0.007162738,0.0002595242,0.0001093317,0.000174589,0.0004068202,0.0001016178,0.0000563588],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1226901,"threshold_uncertainty_score":0.9997079,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008200051569662687,"score_gpt":0.2409061623561485,"score_spread":0.2327061107864858,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}