{"id":"W2067034947","doi":"10.1002/adsc.200404032","title":"Asymmetric Dihydroxylation of Cinnamonitrile to <i>trans</i>‐3‐[(5<i>S</i>,6<i>R</i>)‐5,6‐Dihydroxycyclohexa‐1,3‐dienyl]‐acrylonitrile using Chlorobenzene Dioxygenase in <i>Escherichia coli</i> (pTEZ30)","year":2004,"lang":"en","type":"article","venue":"Advanced Synthesis & Catalysis","topic":"Enzyme Catalysis and Immobilization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Brock University","funders":"Natural Sciences and Engineering Research Council of Canada; Brock University","keywords":"Dihydroxylation; Chemistry; Chlorobenzene; Escherichia coli; Dioxygenase; Stereochemistry; Acrylonitrile; Cofactor; Substrate (aquarium); Enantiomeric excess; Dehydrogenase; Fluorobenzene; Yield (engineering); Biotransformation; Enzyme; Enantioselective synthesis; Catalysis; Organic chemistry; Biochemistry; Benzene; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001943764,0.0005187525,0.0002767428,0.0001547212,0.0001126363,0.0003080774,0.0002318645,0.0001951132,0.0005790863],"category_scores_gemma":[0.000155623,0.0001501373,0.0003468147,0.0002250455,0.0001727955,0.0002070902,0.0002481532,0.000404328,0.0003147889],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004884523,"about_ca_system_score_gemma":0.0004246453,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001910063,"about_ca_topic_score_gemma":0.002715426,"domain_scores_codex":[0.9997616,0.00004159732,0.0000192023,0.0000448758,0.0000532899,0.00007945127],"domain_scores_gemma":[0.9998699,0.0000184488,0.00003454113,0.00002024246,0.00002358503,0.00003321123],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002917775,0.00001503556,0.00008272238,0.00001863564,0.00000322699,0.00002312083,0.000006682061,0.00008460224,0.9990985,0.00004532371,0.0000113977,0.0005816481],"study_design_scores_gemma":[0.000002070054,0.00003521588,0.0003989016,9.873788e-7,0.000002428327,0.00002240852,0.000005823033,0.0002701614,0.999038,0.000006054089,0.0002157794,0.000002334712],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903852,0.0004564495,0.006717113,0.00006472712,0.00002675946,0.00004606605,0.0003915977,0.00007777262,0.001834333],"genre_scores_gemma":[0.9930253,0.0003361315,0.004598479,0.00001958802,0.00000351161,0.00002032272,0.0004702209,0.00003122491,0.001495239],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001910063,"threshold_uncertainty_score":0.003797948,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008200051569662687,"score_gpt":0.2409061623561485,"score_spread":0.2327061107864858,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}