{"id":"W2067053006","doi":"10.1371/journal.pgen.0030041","title":"Deletion of Complement Factor H–Related Genes CFHR1 and CFHR3 Is Associated with Atypical Hemolytic Uremic Syndrome","year":2007,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":324,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"Deutsche Forschungsgemeinschaft; Kidneeds","keywords":"Factor H; Biology; Alternative complement pathway; Complement factor I; Genetics; Atypical hemolytic uremic syndrome; Complement system; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002190392,0.0005176328,0.0003628005,0.0007271525,0.0004301514,0.0001845708,0.0002676053,0.0006120163,0.001147894],"category_scores_gemma":[0.0007713281,0.0001314089,0.0003096637,0.0004899372,0.000549281,0.0001240219,0.000333078,0.0004715379,0.000112813],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001949099,"about_ca_system_score_gemma":0.0001783075,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001460401,"about_ca_topic_score_gemma":0.001407377,"domain_scores_codex":[0.9997601,0.00005130446,0.00002180504,0.00006444024,0.00006271828,0.00003966339],"domain_scores_gemma":[0.9995669,0.0001472347,0.0001413756,0.00002783357,0.00002608734,0.00009059928],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002117915,0.0002211576,0.4931293,0.0001445867,0.0003003166,0.03938302,0.0008374701,0.0006835668,0.4430869,0.0007710741,0.0005262643,0.01879841],"study_design_scores_gemma":[0.00008716794,0.0003573824,0.9055541,0.00002146146,0.000143795,0.07360157,0.0001784047,0.001117765,0.01745124,0.0004857388,0.0009683858,0.00003305031],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992113,0.0001372566,0.0003809052,0.00002827064,0.000003303044,0.000004848632,0.00005339967,0.00001034234,0.000170312],"genre_scores_gemma":[0.9994568,0.00007016119,0.0002816253,0.00002096384,0.000008081171,0.000002787086,0.00006733547,0.00000336916,0.00008889131],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001460401,"threshold_uncertainty_score":0.003840089,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02485796640607892,"score_gpt":0.2449609194229184,"score_spread":0.2201029530168394,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}