{"id":"W2067055201","doi":"10.1254/jphs.13239fp","title":"Inhibition of Smooth Muscle Cell Proliferation by Ezetimibe via the Cyclin D1-MAPK Pathway","year":2014,"lang":"en","type":"article","venue":"Journal of Pharmacological Sciences","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta; University of Calgary; London Health Sciences Centre; Western University","funders":"Construct Program of the Key Discipline in Hunan Province; National Natural Science Foundation of China","keywords":"Ezetimibe; Cyclin D1; Cell growth; Vascular smooth muscle; MAPK/ERK pathway; Chemistry; Cell cycle; Cyclin; Cell biology; Cyclin D; Cyclin A; Signal transduction; Cancer research; Biology; Cell; Endocrinology; Statin; Biochemistry; Smooth muscle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000799614,0.0003084542,0.0002849229,0.0001848575,0.0001525363,0.0001913769,0.0001143871,0.0001634761,0.0009410362],"category_scores_gemma":[0.00008579931,0.0001024872,0.0001935388,0.0001413249,0.0001382621,0.0001398362,0.0001137754,0.0005337386,0.0001997192],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002649445,"about_ca_system_score_gemma":0.0002589903,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004728524,"about_ca_topic_score_gemma":0.001272852,"domain_scores_codex":[0.9999385,0.00001126669,0.000007295364,0.00000953056,0.00001264939,0.00002077513],"domain_scores_gemma":[0.9999757,0.000006137316,0.000005787941,0.000002638691,0.000003924393,0.000005824243],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005914197,0.00009321977,0.0003192858,0.0001693944,0.00001297735,0.00008362424,0.00001454423,0.00009820238,0.993056,0.000167757,0.0001309653,0.005262569],"study_design_scores_gemma":[0.0001171884,0.0006677292,0.005377747,0.000009189979,0.00002997583,0.0001716056,0.00002305613,0.0007140797,0.9861767,0.00006657783,0.006641733,0.000004392541],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9784792,0.01510309,0.002427793,0.0004124604,0.0001136731,0.00006410171,0.0004972779,0.00009447887,0.002807824],"genre_scores_gemma":[0.9866965,0.008325215,0.001819194,0.00009915089,0.0000398971,0.0000692227,0.0005031856,0.000007749422,0.002439915],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009410362,"threshold_uncertainty_score":0.003148079,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01342281222147322,"score_gpt":0.2766411425861404,"score_spread":0.2632183303646672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}