{"id":"W2067074806","doi":"10.1038/gt.2012.43","title":"Efficacy and long-term safety of alipogene tiparvovec (AAV1-LPLS447X) gene therapy for lipoprotein lipase deficiency: an open-label trial","year":2012,"lang":"en","type":"article","venue":"Gene Therapy","topic":"Lipid metabolism and disorders","field":"Medicine","cited_by":399,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Cégep de Chicoutimi; Université du Québec à Chicoutimi","funders":"Canadian Institutes of Health Research; Health Canada; Canada Research Chairs; Heart and Stroke Foundation of Canada","keywords":"Hypertriglyceridemia; Lipoprotein lipase; Pancreatitis; Medicine; Internal medicine; Gastroenterology; Genetic enhancement; Acute pancreatitis; Lipoprotein; Endocrinology; Triglyceride; Biology; Cholesterol; Adipose tissue","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001131349,0.0004070192,0.0008541933,0.0001494836,0.0001936282,0.00005490756,0.0004259101,0.0002130253,0.0002263832],"category_scores_gemma":[0.00006784259,0.0003153672,0.000115455,0.0002744038,0.0001814843,0.0003544342,0.00008985463,0.0001350588,0.00001290209],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002866591,"about_ca_system_score_gemma":0.0002442462,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001390371,"about_ca_topic_score_gemma":0.00001521715,"domain_scores_codex":[0.9975576,0.0001645308,0.0006451666,0.0005399441,0.0003847739,0.0007079749],"domain_scores_gemma":[0.9980959,0.0001102726,0.0002700975,0.0009209712,0.0001536558,0.0004491195],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.170604,0.006241565,0.002059914,0.00005310275,0.0002484966,0.000002337349,0.001484287,0.000002565119,0.4564166,0.0003506732,0.0002597072,0.3622767],"study_design_scores_gemma":[0.4503661,0.0117117,0.06075574,0.00004960503,0.000245039,0.00004717903,0.00008852246,0.00003329356,0.4568509,0.0002174655,0.01884265,0.0007918324],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9617285,0.03018179,0.0009239498,0.0003441802,0.0007497261,0.005704366,0.00009764255,0.00006381064,0.0002060381],"genre_scores_gemma":[0.9751189,0.01432572,0.005823646,0.001450907,0.002095573,0.0003848746,0.0002669459,0.0001230276,0.0004104029],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3614849,"threshold_uncertainty_score":0.9999298,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07772679673581326,"score_gpt":0.3550713739956776,"score_spread":0.2773445772598644,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}