{"id":"W2067117895","doi":"10.1111/epi.12564","title":"Recommendations for <scp>HLA</scp>‐B*15:02 and <scp>HLA</scp>‐A*31:01 genetic testing to reduce the risk of carbamazepine‐induced hypersensitivity reactions","year":2014,"lang":"en","type":"review","venue":"Epilepsia","topic":"Drug-Induced Adverse Reactions","field":"Medicine","cited_by":208,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Health Sciences Centre; Sunnybrook Health Science Centre; Child and Family Research Institute; SickKids Foundation; University of Toronto; BC Children's Hospital; Hospital for Sick Children; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Carbamazepine; Toxic epidermal necrolysis; Medicine; Human leukocyte antigen; HLA-B; Genetic testing; Immunology; Dermatology; Internal medicine; Antigen; Epilepsy; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001836183,0.001125878,0.003104533,0.0008462142,0.000867228,0.0001061637,0.0004447717,0.0007857826,0.000005697597],"category_scores_gemma":[0.02310524,0.0009132641,0.001068009,0.001725608,0.000249765,0.0001924588,0.0002844026,0.001946326,0.0001913502],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005709691,"about_ca_system_score_gemma":0.001133871,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006800503,"about_ca_topic_score_gemma":0.00009960872,"domain_scores_codex":[0.9940899,0.0008413151,0.001916776,0.001459134,0.0005930528,0.00109984],"domain_scores_gemma":[0.980639,0.01389116,0.001958303,0.00202938,0.0007230395,0.0007591647],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000003047097,0.0003770445,0.0001143307,0.005488214,0.001272314,0.00002220733,0.0006232777,0.00002444393,0.002434223,0.0002133812,0.01793911,0.9714884],"study_design_scores_gemma":[0.0007929513,0.000218331,0.004038405,0.007343924,0.006262655,0.0008792848,0.0009625242,0.000278093,0.000197547,0.00008851713,0.9786943,0.0002434953],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.04692394,0.7629654,0.004253118,0.00426431,0.009643571,0.03484528,0.00530888,0.001775496,0.13002],"genre_scores_gemma":[0.01180996,0.94614,0.02689094,0.0005208376,0.003797674,0.001814851,0.0009536208,0.0006822802,0.007389822],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9712449,"threshold_uncertainty_score":0.9993318,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09301752560559966,"score_gpt":0.3487311309348049,"score_spread":0.2557136053292052,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}