{"id":"W2067117895","doi":"10.1111/epi.12564","title":"Recommendations for <scp>HLA</scp>‐B*15:02 and <scp>HLA</scp>‐A*31:01 genetic testing to reduce the risk of carbamazepine‐induced hypersensitivity reactions","year":2014,"lang":"en","type":"review","venue":"Epilepsia","topic":"Drug-Induced Adverse Reactions","field":"Medicine","cited_by":208,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Health Sciences Centre; Sunnybrook Health Science Centre; Child and Family Research Institute; SickKids Foundation; University of Toronto; BC Children's Hospital; Hospital for Sick Children; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Carbamazepine; Toxic epidermal necrolysis; Medicine; Human leukocyte antigen; HLA-B; Genetic testing; Immunology; Dermatology; Internal medicine; Antigen; Epilepsy; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02784694,0.001537674,0.003550002,0.009674007,0.001296466,0.003460472,0.005450562,0.007446078,0.01148858],"category_scores_gemma":[0.1092892,0.001386764,0.008589468,0.00580992,0.001614279,0.004342553,0.003207443,0.005024295,0.003598344],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.006319054,"about_ca_system_score_gemma":0.02778382,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01647126,"about_ca_topic_score_gemma":0.02283385,"domain_scores_codex":[0.9750371,0.01000992,0.009383498,0.001196903,0.003630035,0.0007424941],"domain_scores_gemma":[0.8875684,0.05361785,0.01852579,0.001753408,0.03556137,0.002973348],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005411267,0.0002057663,0.002775348,0.4334457,0.00429182,0.0006511467,0.001378346,0.001634984,0.001380322,0.004685927,0.2353127,0.3136969],"study_design_scores_gemma":[0.001089416,0.0002257345,0.003905083,0.6851688,0.007578128,0.0003436417,0.0008422982,0.0004371599,0.0003884411,0.009003718,0.2908643,0.0001532433],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003955015,0.677157,0.01012353,0.2515191,0.01527987,0.0111758,0.008766279,0.000484626,0.02153874],"genre_scores_gemma":[0.03478606,0.726927,0.084116,0.114345,0.004189915,0.01840703,0.007800654,0.0001746741,0.009253661],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.02784694,"threshold_uncertainty_score":0.1472705,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09301752560559966,"score_gpt":0.3487311309348049,"score_spread":0.2557136053292052,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}