{"id":"W2067175073","doi":"10.1016/j.clinthera.2010.04.018","title":"Buprenorphine transdermal system in adults with chronic low back pain: A randomized, double-blind, placebo-controlled crossover study, followed by an open-label extension phase","year":2010,"lang":"en","type":"article","venue":"Clinical Therapeutics","topic":"Opioid Use Disorder Treatment","field":"Medicine","cited_by":118,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; London Health Sciences Centre; University of Alberta; Hôpital Fleurimont","funders":"Purdue Pharma","keywords":"Medicine; Placebo; Buprenorphine; Visual analogue scale; Anesthesia; Crossover study; Tolerability; Opioid; Analgesic; Randomized controlled trial; Transdermal patch; Oxycodone; Randomization; Transdermal; Adverse effect; Surgery; Internal medicine; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002032546,0.002536041,0.005021009,0.000883252,0.000775867,0.001104544,0.001225033,0.002650491,0.01093488],"category_scores_gemma":[0.002061857,0.001454758,0.001596218,0.0007013959,0.002056765,0.002012026,0.0006794921,0.003204923,0.002060018],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006944779,"about_ca_system_score_gemma":0.001264483,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001208336,"about_ca_topic_score_gemma":0.002245493,"domain_scores_codex":[0.9987587,0.0004995865,0.00009968059,0.0002691125,0.0001218699,0.0002510769],"domain_scores_gemma":[0.9988248,0.0003142325,0.0001969123,0.0001630739,0.0001087503,0.0003922875],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.967585,0.0203192,0.0002927345,0.0002864585,0.0002039547,0.00001737322,0.00005445754,0.0001105005,0.002737586,0.00006055084,0.0002477371,0.008084435],"study_design_scores_gemma":[0.9119821,0.08627295,0.0009606748,0.000008581681,0.0001211662,0.00001103603,0.00001702863,0.0001160788,0.0002936222,0.00003470722,0.0001728399,0.000009228283],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852625,0.001982408,0.0009587647,0.0003458731,0.0004565153,0.008392232,0.00110341,0.0001914706,0.001306673],"genre_scores_gemma":[0.9736656,0.002596408,0.003449546,0.0009314694,0.0009408293,0.01205862,0.001191932,0.00005656713,0.005108953],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01093488,"threshold_uncertainty_score":0.03658086,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06105664667301164,"score_gpt":0.3933878888950649,"score_spread":0.3323312422220533,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}