{"id":"W2067175073","doi":"10.1016/j.clinthera.2010.04.018","title":"Buprenorphine transdermal system in adults with chronic low back pain: A randomized, double-blind, placebo-controlled crossover study, followed by an open-label extension phase","year":2010,"lang":"en","type":"article","venue":"Clinical Therapeutics","topic":"Opioid Use Disorder Treatment","field":"Medicine","cited_by":118,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; London Health Sciences Centre; University of Alberta; Hôpital Fleurimont","funders":"Purdue Pharma","keywords":"Medicine; Placebo; Buprenorphine; Visual analogue scale; Anesthesia; Crossover study; Tolerability; Opioid; Analgesic; Randomized controlled trial; Transdermal patch; Oxycodone; Randomization; Transdermal; Adverse effect; Surgery; Internal medicine; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.005628123,0.0006858197,0.003121808,0.0001272623,0.0001547418,0.000176373,0.0005722999,0.0005067391,0.0001675668],"category_scores_gemma":[0.0001563831,0.0004437116,0.0003108344,0.0003542661,0.0003988884,0.0002670291,0.00008953467,0.001216753,0.00006264777],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001574328,"about_ca_system_score_gemma":0.0005563934,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001868472,"about_ca_topic_score_gemma":0.0007927712,"domain_scores_codex":[0.9939734,0.001408291,0.002095145,0.001174481,0.0006425601,0.0007061005],"domain_scores_gemma":[0.9955232,0.001771283,0.0004962314,0.001437425,0.0002972392,0.0004746487],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9467447,0.03924536,0.003152459,0.0002542046,0.001523161,0.0002016493,0.00109449,0.00001768895,0.0009745967,0.00002819387,0.00008479132,0.006678706],"study_design_scores_gemma":[0.9518661,0.01442468,0.0002039447,0.000661651,0.001428519,0.00002625547,0.000573391,0.02986123,0.0001465389,0.00000895731,0.0003195484,0.0004791147],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9744294,0.001167548,0.0007124452,0.000776381,0.0005569659,0.02193151,0.00003445759,0.0001345531,0.0002567661],"genre_scores_gemma":[0.9954547,0.0002045859,0.0006526434,0.001053803,0.0002801085,0.001520889,0.0002056581,0.0001482475,0.0004794182],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02984354,"threshold_uncertainty_score":0.9998015,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06105664667301164,"score_gpt":0.3933878888950649,"score_spread":0.3323312422220533,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}