{"id":"W2067193484","doi":"10.1074/jbc.m112.425769","title":"Drug Uptake, Lipid Rafts, and Vesicle Trafficking Modulate Resistance to an Anticancer Lysophosphatidylcholine Analogue in Yeast","year":2013,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; University of Calgary","funders":"European Regional Development Fund; Junta de Castilla y León; Ministerio de Ciencia e Innovación; Instituto de Salud Carlos III; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; European Commission; University of Calgary","keywords":"Internalization; Cell biology; Endocytosis; Vacuole; Lipid raft; Biology; Endoplasmic reticulum; Lysosome; Biochemistry; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002756185,0.000138613,0.0002354408,0.00002505422,0.00003285293,0.00002773559,0.0001514473,0.0001560982,0.00006231409],"category_scores_gemma":[0.00005181752,0.000109124,0.00007569932,0.0001021204,0.00005870595,0.00001322338,0.00002792191,0.0001658217,0.000001812112],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001748219,"about_ca_system_score_gemma":0.00002982007,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008220743,"about_ca_topic_score_gemma":0.00002223818,"domain_scores_codex":[0.9989973,0.0000281205,0.0004111794,0.000246329,0.0001100668,0.0002069822],"domain_scores_gemma":[0.9994114,0.000007421054,0.0001406644,0.0001493064,0.00009975062,0.0001914529],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001634212,0.00007822426,0.01345943,0.00001825727,0.00001366894,0.00001389015,0.00005253114,0.0001044076,0.9848617,0.000002992619,0.00007757979,0.001153936],"study_design_scores_gemma":[0.001124353,0.0002163432,0.2061782,0.00009541377,0.00001564034,0.00004480066,0.0001960232,0.0001852401,0.7799014,0.00009239613,0.01162994,0.0003202669],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976628,0.001257493,0.0005398588,0.0002738111,0.00004722946,0.00008412899,0.000007618811,0.000004751174,0.0001223291],"genre_scores_gemma":[0.9977865,0.0005018326,0.0009759359,0.0001751622,0.00031642,0.000003929688,0.0001114026,0.000009772511,0.000119022],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2049602,"threshold_uncertainty_score":0.4449948,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01241824452645472,"score_gpt":0.2313597505462608,"score_spread":0.2189415060198061,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}