{"id":"W2067193667","doi":"10.4049/jimmunol.169.12.7026","title":"Hydrogen Peroxide Induces Murine Macrophage Chemokine Gene Transcription Via Extracellular Signal-Regulated Kinase- and Cyclic Adenosine 5′-Monophosphate (cAMP)-Dependent Pathways: Involvement of NF-κB, Activator Protein 1, and cAMP Response Element Binding Protein","year":2002,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier de l'Université Laval; Centre hospitalier universitaire de Québec","funders":"","keywords":"CREB; Chemokine; Cell biology; Protein kinase A; MAPK/ERK pathway; Molecular biology; Chemistry; Signal transduction; Biology; Transcription factor; Kinase; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002152226,0.0003660411,0.0006444535,0.0004008363,0.0002899278,0.00002116699,0.0003425679,0.0003580089,0.000447718],"category_scores_gemma":[0.00008997001,0.0002713236,0.0001182639,0.0002181202,0.0004221765,0.000297765,0.0001301544,0.000659911,0.00002411701],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001509078,"about_ca_system_score_gemma":0.000060829,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006477187,"about_ca_topic_score_gemma":0.000002881402,"domain_scores_codex":[0.9963631,0.00151061,0.00124462,0.0002579231,0.0001497638,0.0004740015],"domain_scores_gemma":[0.9980953,0.0001456631,0.001181179,0.0003481333,0.000185278,0.00004448216],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009643016,0.0003425178,0.0000247573,0.00005996873,0.0007803224,0.00004217508,0.002432883,0.00001505264,0.9800866,0.00002925163,0.000009867074,0.006533608],"study_design_scores_gemma":[0.004556952,0.002317064,0.001088527,0.0002290229,0.0001693989,0.0007181648,0.0007676509,0.00002816068,0.9891776,0.00009157157,0.0006101403,0.0002457109],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.952777,0.04511852,0.0001985178,0.0007310093,0.0001223068,0.001012621,0.00001362231,0.00002235571,0.000004059932],"genre_scores_gemma":[0.9970653,0.001980173,0.0001241098,0.00002110631,0.00002926172,0.00004032537,0.00001913775,0.0000370186,0.0006835866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04428829,"threshold_uncertainty_score":0.9999739,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01416180484691815,"score_gpt":0.1989751075511568,"score_spread":0.1848133027042387,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}