{"id":"W2067258891","doi":"10.1038/srep01350","title":"Collapsin response mediator protein 3 deacetylates histone H4 to mediate nuclear condensation and neuronal death","year":2013,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Axon Guidance and Neuronal Signaling","field":"Neuroscience","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; National Research Council Canada","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Histone deacetylase 5; Histone; HDAC11; Excitotoxicity; Biology; Histone H4; Histone deacetylase; Cell biology; Acetylation; HDAC10; Mediator; Histone deacetylase 2; Neuroprotection; Chemistry; Programmed cell death; Apoptosis; Biochemistry; Neuroscience; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001279628,0.0005041942,0.0002414364,0.0001855765,0.000214142,0.0002247251,0.0001992944,0.0001986547,0.001073521],"category_scores_gemma":[0.0001393201,0.0001189432,0.0003540024,0.0001447178,0.0003780606,0.0002386598,0.0003638236,0.0003747629,0.000438521],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004889666,"about_ca_system_score_gemma":0.0002962773,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008734892,"about_ca_topic_score_gemma":0.001743403,"domain_scores_codex":[0.9999067,0.000009102997,0.000006260654,0.00002444427,0.00002398361,0.00002956293],"domain_scores_gemma":[0.9999133,0.000008865496,0.00003753982,0.00001166145,0.000009885951,0.00001864961],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008465118,0.000004604136,0.0002054018,0.00003475025,0.000007291033,0.0001202634,0.00001402652,0.0000348072,0.9980295,0.0001431841,0.00004991001,0.001271478],"study_design_scores_gemma":[0.00001406829,0.00009785365,0.006249532,0.000004629428,0.00001344081,0.0004670973,0.00003289972,0.0003468032,0.9900308,0.0001689029,0.002569371,0.00000464562],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.981988,0.006276402,0.007659177,0.0001834681,0.00007555042,0.0000274785,0.0003919236,0.0001368242,0.003261246],"genre_scores_gemma":[0.9911082,0.001970062,0.002669407,0.00008306818,0.00001927682,0.00002337649,0.0006058487,0.00003121367,0.003489695],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001073521,"threshold_uncertainty_score":0.003591239,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02494868358049203,"score_gpt":0.2654736983203843,"score_spread":0.2405250147398922,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}