{"id":"W2067305597","doi":"10.1074/jbc.m710323200","title":"Crystal Structure of Human Spermine Synthase","year":2008,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":119,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"National Institute of General Medical Sciences; Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; U.S. Public Health Service; Stiftelsen för Strategisk Forskning; Ontario Genomics Institute; Canadian Institutes of Health Research; Ontario Genomics; Genome Canada; GlaxoSmithKline; Ontario Innovation Trust; Wellcome Trust","keywords":"Spermine; Spermidine; Active site; ATP synthase; Polyamine; Biochemistry; Mutagenesis; Stereochemistry; Binding site; Chemistry; Lyase; Enzyme; Biology; Mutation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006095117,0.0001090746,0.0002251301,0.00001367777,0.00005059153,0.000002856767,0.0002427038,0.0001736149,0.0001383553],"category_scores_gemma":[0.0001156111,0.00007604121,0.0001516629,0.00005944475,0.0002098321,0.000002430631,0.00006306599,0.0001343696,5.532295e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004810791,"about_ca_system_score_gemma":0.00004713457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001271665,"about_ca_topic_score_gemma":1.965078e-7,"domain_scores_codex":[0.9992735,0.0000169144,0.0003553136,0.0001259568,0.0001028357,0.0001254852],"domain_scores_gemma":[0.9993023,0.00001070363,0.0002928779,0.0001815454,0.0001155392,0.00009705875],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003736566,0.00009360926,0.002350101,0.00001072046,0.00002551201,0.000009797481,0.000006485473,0.000002795478,0.9966511,0.000012562,0.0006835943,0.0001164086],"study_design_scores_gemma":[0.0003684661,0.0001528873,0.005509357,0.000006983798,0.00001297372,0.0005137463,0.00002160587,7.297113e-7,0.987664,0.0001610647,0.005498882,0.00008931549],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983541,0.0008849619,0.0001339553,0.00003904898,0.00002866229,0.00002976156,0.00006535526,0.000002634644,0.0004615467],"genre_scores_gemma":[0.9985325,0.0002023278,0.0004394448,0.00004007639,0.0005597204,6.283778e-7,0.00005114267,0.000005964375,0.0001681378],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00898706,"threshold_uncertainty_score":0.310087,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0187737413083587,"score_gpt":0.2675391368680255,"score_spread":0.2487653955596668,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}