{"id":"W2067305597","doi":"10.1074/jbc.m710323200","title":"Crystal Structure of Human Spermine Synthase","year":2008,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":119,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"National Institute of General Medical Sciences; Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; U.S. Public Health Service; Stiftelsen för Strategisk Forskning; Ontario Genomics Institute; Canadian Institutes of Health Research; Ontario Genomics; Genome Canada; GlaxoSmithKline; Ontario Innovation Trust; Wellcome Trust","keywords":"Spermine; Spermidine; Active site; ATP synthase; Polyamine; Biochemistry; Mutagenesis; Stereochemistry; Binding site; Chemistry; Lyase; Enzyme; Biology; Mutation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002268964,0.0003773801,0.0005212918,0.0001385526,0.0003182425,0.0006181764,0.0003942091,0.0005178104,0.003842142],"category_scores_gemma":[0.0003349035,0.0002906575,0.0002059563,0.0004441468,0.0001340152,0.0002590777,0.0001395988,0.0007065271,0.001156834],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001182493,"about_ca_system_score_gemma":0.0008138601,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003432224,"about_ca_topic_score_gemma":0.004340793,"domain_scores_codex":[0.999878,0.00001757492,0.000007555248,0.0000343552,0.00004430251,0.00001818617],"domain_scores_gemma":[0.99989,0.00001971959,0.0000143936,0.000004931647,0.00004081239,0.0000301709],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002398134,0.0006204197,0.006509969,0.001617116,0.0003159412,0.001528011,0.0006901015,0.01312624,0.8699944,0.006661031,0.04597362,0.05056506],"study_design_scores_gemma":[0.001991499,0.00133453,0.05691934,0.0003598836,0.0004421248,0.003739346,0.0007328712,0.07323252,0.4268688,0.006095678,0.4280506,0.0002328974],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9038956,0.03607349,0.009811314,0.002876104,0.000645266,0.0002338858,0.01409596,0.001281044,0.03108732],"genre_scores_gemma":[0.8792578,0.008307897,0.01893465,0.0007757919,0.00008648372,0.0002007015,0.06357644,0.0001675167,0.02869281],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003842142,"threshold_uncertainty_score":0.01285326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0187737413083587,"score_gpt":0.2675391368680255,"score_spread":0.2487653955596668,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}