{"id":"W2067326341","doi":"10.1089/cbr.2012.1200.271","title":"Preclinical Evaluation of VB6-845: An Anti-EpCAM Immunotoxin with Reduced Immunogenic Potential","year":2012,"lang":"en","type":"article","venue":"Cancer Biotherapy and Radiopharmaceuticals","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Viventia Bio (Canada)","funders":"","keywords":"Immunotoxin; Epithelial cell adhesion molecule; Pharmacology; Medicine; Immunotherapy; Adverse effect; Pharmacokinetics; Antibody; Immunology; Monoclonal antibody; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001572075,0.0003144162,0.0005236689,0.0001052778,0.0002740264,0.00002922972,0.0002594166,0.0003946976,0.004024379],"category_scores_gemma":[0.00002912641,0.0002386311,0.0001270595,0.0001812829,0.0007332597,0.0004065067,0.00003366131,0.000391994,0.00002497679],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005691775,"about_ca_system_score_gemma":0.0002404189,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003180873,"about_ca_topic_score_gemma":0.000001335634,"domain_scores_codex":[0.997599,0.0006961469,0.0005365404,0.0004056543,0.000144655,0.0006179868],"domain_scores_gemma":[0.9989629,0.00007713633,0.0002381056,0.0004359467,0.0001770253,0.0001088645],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009322449,0.0003782407,0.002071934,0.00002709958,0.0006090799,6.21351e-7,0.0007554887,0.00002951304,0.952873,0.0003997581,0.00004182623,0.04188121],"study_design_scores_gemma":[0.007529112,0.0006191987,0.03171503,0.00008625112,0.0005331931,0.00009730752,0.0002422189,0.000176861,0.9522536,0.0000491185,0.00627521,0.0004228466],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8646386,0.1327047,0.0002640681,0.0001254595,0.001364517,0.0007062753,0.00006194298,0.00004829414,0.00008619542],"genre_scores_gemma":[0.9919506,0.006967152,0.0002828454,0.0002042389,0.0001882814,0.0001150129,0.00004113261,0.00004632994,0.000204357],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.127312,"threshold_uncertainty_score":0.9968861,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06114198218091945,"score_gpt":0.3889204511167967,"score_spread":0.3277784689358773,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}