{"id":"W2067354786","doi":"10.1038/onc.2011.265","title":"Neutralization of the γ-secretase activity by monoclonal antibody against extracellular domain of nicastrin","year":2011,"lang":"en","type":"article","venue":"Oncogene","topic":"Infectious Diseases and Mycology","field":"Veterinary","cited_by":66,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Core Research for Evolutional Science and Technology; National Institute on Aging; Institut national de la recherche scientifique; Washington University in St. Louis; Japan Society for the Promotion of Science; Ministry of Education, Culture, Sports, Science and Technology; University of Texas Southwestern Medical Center; University of Chicago","keywords":"Nicastrin; Biology; Presenilin; Notch signaling pathway; Extracellular; Immunogen; Amyloid precursor protein secretase; Monoclonal antibody; Cell biology; Proprotein Convertases; Signal transduction; Cancer research; Antibody; Molecular biology; Biochemistry; Immunology; Amyloid precursor protein; LDL receptor; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001457604,0.000105586,0.0001843739,0.00003333547,0.00005417238,0.000002584151,0.0001563098,0.00009079084,0.0003438694],"category_scores_gemma":[0.00001571998,0.00008389532,0.0001461321,0.0001349821,0.0001042314,0.0000560347,0.00007462878,0.00007110557,0.00000788774],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002530935,"about_ca_system_score_gemma":0.00005857724,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002451634,"about_ca_topic_score_gemma":0.00001618622,"domain_scores_codex":[0.9991791,0.0001723344,0.0002161355,0.0001596159,0.0001142219,0.0001585531],"domain_scores_gemma":[0.9993258,0.00002743733,0.000229198,0.0003123703,0.00005605543,0.00004910625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002596898,0.0005359435,0.01831436,0.00003789138,0.00005095353,0.00001914867,0.000135182,0.000008931151,0.978261,0.000820431,0.0002753311,0.001281157],"study_design_scores_gemma":[0.001603599,0.001196399,0.1071566,0.00004538148,0.0001552332,0.00007738479,0.00008659271,0.0002795758,0.8824909,0.0006365507,0.005966042,0.0003057279],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99479,0.0002831277,0.001153769,0.00001757748,0.0001511501,0.0002068836,0.0001868899,0.00001616542,0.00319445],"genre_scores_gemma":[0.9995291,0.00005493161,0.0001926991,0.00003031238,0.00003124881,0.000008304392,0.00004504398,0.00001503115,0.00009333198],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09577009,"threshold_uncertainty_score":0.3765128,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04327836604502393,"score_gpt":0.3017167593657374,"score_spread":0.2584383933207135,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}