{"id":"W2067354786","doi":"10.1038/onc.2011.265","title":"Neutralization of the γ-secretase activity by monoclonal antibody against extracellular domain of nicastrin","year":2011,"lang":"en","type":"article","venue":"Oncogene","topic":"Infectious Diseases and Mycology","field":"Veterinary","cited_by":66,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Core Research for Evolutional Science and Technology; National Institute on Aging; Institut national de la recherche scientifique; Washington University in St. Louis; Japan Society for the Promotion of Science; Ministry of Education, Culture, Sports, Science and Technology; University of Texas Southwestern Medical Center; University of Chicago","keywords":"Nicastrin; Biology; Presenilin; Notch signaling pathway; Extracellular; Immunogen; Amyloid precursor protein secretase; Monoclonal antibody; Cell biology; Proprotein Convertases; Signal transduction; Cancer research; Antibody; Molecular biology; Biochemistry; Immunology; Amyloid precursor protein; LDL receptor; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002963287,0.0006351383,0.0003081999,0.0003104243,0.0001989726,0.0003228647,0.0004986452,0.0005420026,0.001794982],"category_scores_gemma":[0.000307568,0.0002850577,0.0004893197,0.0002144176,0.0003694521,0.0003546471,0.0002531462,0.001407293,0.0004517726],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005678396,"about_ca_system_score_gemma":0.0003118118,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00136681,"about_ca_topic_score_gemma":0.001140691,"domain_scores_codex":[0.9997312,0.00003891425,0.00002471583,0.0000352459,0.00004767156,0.0001222765],"domain_scores_gemma":[0.9997161,0.0001196685,0.00004187986,0.00004953362,0.00003104699,0.00004170418],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005011588,0.0001285841,0.0001721094,0.00003807927,0.00001625233,0.0001157902,0.00002825041,0.0001222684,0.9976377,0.0002139186,0.00005060527,0.0009751893],"study_design_scores_gemma":[0.0001055714,0.0008150802,0.002112978,0.000007994714,0.00004070123,0.000381018,0.00003264907,0.001492325,0.9933662,0.0000824062,0.001557735,0.000005173495],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952537,0.001119782,0.001205875,0.0001321546,0.00006338983,0.00002871424,0.0001126341,0.0000340192,0.002049823],"genre_scores_gemma":[0.995344,0.0008262017,0.0007749081,0.0000639601,0.00003105959,0.00002832572,0.0003802801,0.00001013739,0.002541061],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001794982,"threshold_uncertainty_score":0.00600487,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04327836604502393,"score_gpt":0.3017167593657374,"score_spread":0.2584383933207135,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}