{"id":"W2067368224","doi":"10.1242/jcs.02427","title":"Decreased origin usage and initiation of DNA replication in haploinsufficient HCT116 Ku80+/- cells","year":2005,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Biology; Haploinsufficiency; Ku80; Replication (statistics); DNA replication; Genetics; Cell biology; DNA; Virology; DNA-binding protein; Gene; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007516494,0.0004123991,0.0003287789,0.0003071542,0.0001116669,0.0003260206,0.0001999305,0.0003290946,0.001636146],"category_scores_gemma":[0.0001352623,0.0001934724,0.0001780374,0.0002236858,0.0001710265,0.0001620135,0.0001837578,0.0005099238,0.0005252571],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002792077,"about_ca_system_score_gemma":0.0001653342,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001402271,"about_ca_topic_score_gemma":0.001254944,"domain_scores_codex":[0.9998659,0.00001437509,0.00002273295,0.00003711416,0.0000396082,0.000020229],"domain_scores_gemma":[0.9998147,0.00002529082,0.00006267584,0.00002645972,0.00001961224,0.00005118801],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003396248,0.000008140662,0.0001349828,0.00001464178,0.000002057216,0.00002793331,0.000005945251,0.0000305471,0.9993168,0.0000228299,0.00001416849,0.0003880225],"study_design_scores_gemma":[0.0000144808,0.0002032735,0.01441989,0.000007138882,0.00001318991,0.0003887131,0.00002908646,0.001292526,0.981847,0.00002744056,0.001751594,0.000005606611],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955595,0.001116464,0.001361407,0.00005781174,0.00002705949,0.00001748612,0.001098696,0.000146286,0.0006154134],"genre_scores_gemma":[0.991631,0.0007279852,0.001657866,0.00004210429,0.000008898517,0.00002835667,0.001826784,0.00004187927,0.00403513],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001636146,"threshold_uncertainty_score":0.005473435,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01077657778936494,"score_gpt":0.2609620418555311,"score_spread":0.2501854640661662,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}