{"id":"W2067368224","doi":"10.1242/jcs.02427","title":"Decreased origin usage and initiation of DNA replication in haploinsufficient HCT116 Ku80+/- cells","year":2005,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Biology; Haploinsufficiency; Ku80; Replication (statistics); DNA replication; Genetics; Cell biology; DNA; Virology; DNA-binding protein; Gene; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001155956,0.00005594024,0.00008784488,0.0001217401,0.00002990001,0.00001687075,0.0001931224,0.0000400748,0.000006851168],"category_scores_gemma":[0.0001267866,0.00004886053,0.00003010091,0.000204251,0.0001040844,0.00002119225,0.00004248929,0.00005270002,0.000001281436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003204022,"about_ca_system_score_gemma":0.000199088,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003667715,"about_ca_topic_score_gemma":0.000007577481,"domain_scores_codex":[0.9991413,0.00002961128,0.0002900951,0.0001705652,0.0002497756,0.0001186793],"domain_scores_gemma":[0.9992518,0.00001187696,0.0003055494,0.0001990409,0.0001513209,0.00008044685],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002239038,0.00009299269,0.0003735322,0.000005195247,0.000001048029,0.000001167203,0.00007085051,0.0001989982,0.9973994,0.00004668673,0.00003293171,0.001754763],"study_design_scores_gemma":[0.0003286805,0.0002417556,0.002588909,0.00001525454,0.000005432425,0.00001730692,0.00004258806,0.0009046131,0.9938441,0.00004776946,0.001911599,0.00005199074],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971859,0.0001756295,0.001586509,0.00007738355,0.0000601475,0.00006599401,0.000001189105,0.00000140185,0.0008458737],"genre_scores_gemma":[0.9931446,0.0001165145,0.006553265,0.00007581725,0.00004656557,8.172976e-7,7.634405e-7,0.000003655097,0.00005794562],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004966756,"threshold_uncertainty_score":0.1992475,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01077657778936494,"score_gpt":0.2609620418555311,"score_spread":0.2501854640661662,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}