{"id":"W2067392953","doi":"10.2164/jandrol.111.015982","title":"Human Sperm Chromatin Undergoes Physiological Remodeling During In Vitro Capacitation and Acrosome Reaction","year":2012,"lang":"en","type":"article","venue":"Journal of Andrology","topic":"Sperm and Testicular Function","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Victoria Hospital; McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"Sperm; Capacitation; Chromatin; DNA fragmentation; Acrosome reaction; Histone; Cell biology; Acrosome; Chromatin remodeling; Chemistry; Biology; Molecular biology; Biochemistry; Andrology; DNA; Apoptosis; Programmed cell death; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000268426,0.0002778947,0.0001188071,0.000179106,0.0001421499,0.0002404768,0.0001515787,0.0001802934,0.001615579],"category_scores_gemma":[0.0002256901,0.0001523558,0.0001795225,0.0001628974,0.0001705474,0.0001617166,0.0001641484,0.000241464,0.0004241628],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000194899,"about_ca_system_score_gemma":0.0001517855,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008766522,"about_ca_topic_score_gemma":0.001285907,"domain_scores_codex":[0.9998473,0.00004590048,0.00001246914,0.00002907213,0.00002997214,0.0000352988],"domain_scores_gemma":[0.999855,0.0000371474,0.00003129073,0.00001938669,0.00003102961,0.00002607422],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001662431,0.000008413218,0.0005830368,0.00002877015,0.00000547751,0.00005107951,0.00003679337,0.00002359145,0.9984798,0.00002408526,0.0000160759,0.0005766687],"study_design_scores_gemma":[0.00001519198,0.0005880661,0.04094891,0.000009558408,0.00002083615,0.0003358834,0.00008335191,0.0002970597,0.9558105,0.00003279269,0.001850241,0.00000764685],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937384,0.002324524,0.001913854,0.00005231252,0.00001599842,0.00004101701,0.000320652,0.00003720804,0.001556003],"genre_scores_gemma":[0.9957052,0.0006547219,0.000688142,0.00004724254,0.00001059135,0.00003347073,0.0009302285,0.00001090031,0.001919592],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001615579,"threshold_uncertainty_score":0.005404651,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03046314253554044,"score_gpt":0.2903400039244326,"score_spread":0.2598768613888922,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}