{"id":"W2067454244","doi":"10.1089/vim.2004.17.327","title":"Adenoviral Vectors for Gene Replacement Therapy","year":2004,"lang":"en","type":"review","venue":"Viral Immunology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Canadian Institutes of Health Research","funders":"","keywords":"Limiting; Genetic enhancement; Viral vector; Gene; Vector (molecular biology); Gene delivery; Computational biology; Biology; Immune system; Virology; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003866926,0.0006285122,0.001140588,0.0002190306,0.0001585027,0.00003847824,0.0008743076,0.0009715393,0.00009552692],"category_scores_gemma":[0.00006252746,0.0005363767,0.0008087977,0.0001718001,0.0002491262,0.000003761315,0.0002456903,0.0004003957,0.0001221836],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001887412,"about_ca_system_score_gemma":0.0009429246,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002332928,"about_ca_topic_score_gemma":0.00001645965,"domain_scores_codex":[0.9971181,0.0003210568,0.0006284785,0.0009506029,0.0001726348,0.0008090877],"domain_scores_gemma":[0.9982889,0.00003608414,0.0002953976,0.001193335,0.0001079313,0.00007837344],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003814599,0.0002175507,0.000001073281,0.001212446,0.001926173,0.000008616182,0.00002138135,0.00000448422,0.0555064,0.00007393768,0.0009225995,0.9362907],"study_design_scores_gemma":[0.001778239,0.01272119,8.238725e-7,0.0003438195,0.00009669317,0.00005185634,0.000004902442,3.422468e-7,0.03178198,0.00007629735,0.9526087,0.0005351633],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00228823,0.9946916,0.0001400164,0.00003841469,0.0005958151,0.001962445,0.0001631155,0.00003761654,0.0000827987],"genre_scores_gemma":[0.0001273066,0.9938302,0.0002787951,0.0001291599,0.0005754853,0.001056159,0.00190832,0.0001797225,0.001914851],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9516861,"threshold_uncertainty_score":0.9997088,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04662582388975435,"score_gpt":0.3645321146834446,"score_spread":0.3179062907936903,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}