{"id":"W2067454244","doi":"10.1089/vim.2004.17.327","title":"Adenoviral Vectors for Gene Replacement Therapy","year":2004,"lang":"en","type":"review","venue":"Viral Immunology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Canadian Institutes of Health Research","funders":"","keywords":"Limiting; Genetic enhancement; Viral vector; Gene; Vector (molecular biology); Gene delivery; Computational biology; Biology; Immune system; Virology; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005435619,0.0009172873,0.001020341,0.001746756,0.0002979897,0.0009677818,0.0008800187,0.0009373356,0.005261501],"category_scores_gemma":[0.0002743056,0.0002899391,0.0003730452,0.001767838,0.0005630946,0.001079728,0.0004904433,0.001981607,0.008305824],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007147896,"about_ca_system_score_gemma":0.0006230301,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005142289,"about_ca_topic_score_gemma":0.0005545394,"domain_scores_codex":[0.9996692,0.00004650161,0.00002569288,0.00005022487,0.0001828265,0.00002556392],"domain_scores_gemma":[0.9998941,0.00003183272,0.00001603325,0.000009914331,0.00002900675,0.00001908664],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007038538,0.0001330912,0.00018102,0.004379685,0.00004599156,0.0004196573,0.0001030404,0.0005096287,0.05170958,0.01810641,0.04694313,0.8773984],"study_design_scores_gemma":[0.0000150566,0.0000433141,0.0001556137,0.0002979199,0.00001383178,0.0007910699,0.00001665619,0.00007682599,0.005409868,0.001645833,0.9915227,0.00001119925],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007714264,0.9762655,0.007967848,0.0004474545,0.0007690259,0.00006829159,0.000125236,0.0001539754,0.01343119],"genre_scores_gemma":[0.004351882,0.9747555,0.00677183,0.0003591999,0.0002481933,0.00008966106,0.0003551213,0.00002196753,0.0130467],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005261501,"threshold_uncertainty_score":0.01760149,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04662582388975435,"score_gpt":0.3645321146834446,"score_spread":0.3179062907936903,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}