{"id":"W2067538155","doi":"10.1021/jm030423m","title":"Synthesis of a Prodrug Designed To Release Multiple Inhibitors of the Epidermal Growth Factor Receptor Tyrosine Kinase and an Alkylating Agent:  A Novel Tumor Targeting Concept","year":2003,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Royal Victoria Regional Health Centre; Royal Victoria Hospital; Health Canada","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Prodrug; Epidermal growth factor receptor; Tyrosine kinase; Receptor tyrosine kinase; Epidermal growth factor; Comet assay; Growth factor receptor; Biochemistry; Pharmacology; Kinase; Receptor; DNA damage; DNA; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001286143,0.0003878048,0.0003197674,0.000183433,0.0001272488,0.0001620038,0.000258577,0.000379737,0.0007189555],"category_scores_gemma":[0.0001190364,0.0001699307,0.0002041757,0.0001425906,0.000163312,0.0002798233,0.0001803911,0.000536565,0.0003127837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002110031,"about_ca_system_score_gemma":0.0002746248,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002542155,"about_ca_topic_score_gemma":0.0004169943,"domain_scores_codex":[0.9999377,0.000007083849,0.000006761171,0.00001627056,0.00001861683,0.00001360053],"domain_scores_gemma":[0.9999361,0.00001078023,0.00001996057,0.000008853446,0.000009693536,0.00001467288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000438118,0.00003877292,0.00003371716,0.00005982717,0.000004359896,0.0001023172,0.0000161363,0.0002798053,0.9920145,0.0003038799,0.00004259234,0.007060183],"study_design_scores_gemma":[0.00007612013,0.001024933,0.0003347747,0.000005656695,0.00002017975,0.0005483128,0.000006320292,0.0007070282,0.9899811,0.00009272114,0.007194954,0.000007871658],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8908721,0.006718013,0.09471095,0.0004669325,0.0002746626,0.0007572487,0.0005069009,0.0003461948,0.00534696],"genre_scores_gemma":[0.9168508,0.003012475,0.07306842,0.000164078,0.00004812163,0.0002374332,0.0003660241,0.00004074207,0.006211892],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007189555,"threshold_uncertainty_score":0.002405107,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01837996129702122,"score_gpt":0.2400577250411946,"score_spread":0.2216777637441734,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}